ArticleJournal of experimental botany2014
Cyclic GMP is involved in auxin signalling during Arabidopsis root growth and development.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- A new plant guanosine cyclase ZjGC found from jujube regulates growth and development via endogenous hormones.Frontiers in plant science · 2025Article
- Article
- Modulating root system architecture: cross-talk between auxin and phytohormones.Frontiers in plant science · 2024Review
- Role ofFrontiers in plant science · 2024Article
- Article
- Developing aMarine drugs · 2022Article
- Understanding the Intricate Web of Phytohormone Signalling in Modulating Root System Architecture.International journal of molecular sciences · 2021Review
- Moonlighting Proteins Shine New Light on Molecular Signaling Niches.International journal of molecular sciences · 2021Review
- Dual Activities of Receptor-Like Kinase OsWAKL21.2 Induce Immune Responses.Plant physiology · 2020Article
- Peroxynitrite induced signaling pathways in plant response to non-proteinogenic amino acids.Planta · 2020Review
- Characterization of tomato protein kinases embedding guanylate cyclase catalytic center motif.Scientific reports · 2020Article
- Dual Activities of Plant cGMP-Dependent Protein Kinase and Its Roles in Gibberellin Signaling and Salt Stress.The Plant cell · 2019Article
- Involvement of G6PD5 in ABA response during seed germination and root growth in Arabidopsis.BMC plant biology · 2019Article
- Cytosolic Glucose-6-Phosphate Dehydrogenase Is Involved in Seed Germination and Root Growth Under Salinity inFrontiers in plant science · 2019Article
- Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling.Frontiers in plant science · 2017Review
- The plant natriuretic peptide receptor is a guanylyl cyclase and enables cGMP-dependent signaling.Plant molecular biology · 2016Article
- cGMP Signalling Mediates Water Sensation (Hydrosensation) and Hydrotaxis in Caenorhabditis elegans.Scientific reports · 2016Article
- In Search of Enzymes with a Role in 3', 5'-Cyclic Guanosine Monophosphate Metabolism in Plants.Frontiers in plant science · 2016Review
- Plant Hormone Homeostasis, Signaling, and Function during Adventitious Root Formation in Cuttings.Frontiers in plant science · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) plays an important role in plant development and responses to stress. Recent studies indicated that cGMP is a secondary signal generated in response to auxin stimulation. cGMP also mediates auxin-induced adventitious root formation in mung bean and gravitropic bending in soybean. Nonetheless, the mechanism of the participation of cGMP in auxin signalling to affect these growth and developmental processes is largely unknown. In this report we provide evidence that indole-3-acetic acid (IAA) induces cGMP accumulation in Arabidopsis roots through modulation of the guanylate cyclase activity. Application of 8-bromo-cGMP (a cell-permeable cGMP derivative) increases auxin-dependent lateral root formation, root hair development, primary root growth, and gene expression. In contrast, inhibitors of endogenous cGMP synthesis block these processes induced by auxin. Data also showed that 8-bromo-cGMP enhances auxin-induced degradation of Aux/IAA protein modulated by the SCF(TIR1) ubiquitin-proteasome pathway. Furthermore, it was found that 8-bromo-cGMP is unable to directly influence the auxin-dependent TIR1-Aux/IAA interaction as evidenced by pull-down and yeast two-hybrid assays. In addition, we provide evidence for cGMP-mediated modulation of auxin signalling through cGMP-dependent protein kinase (PKG). Our results suggest that cGMP acts as a mediator to participate in auxin signalling and may govern this process by PKG activity via its influence on auxin-regulated gene expression and auxin/IAA degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.