ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2014
Orthostatic hypotension and cognitive impairment: a dangerous association?
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03602014 (Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Cerebral Blood Flow Dynamics in Neurogenic Orthostatic Hypotension: A Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2025Pooled it
- Orthostatic hypotension in patients with Alzheimer's disease: a meta-analysis of prospective studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Impact of scheduled water intake on mild cognitive impairment in patients with orthostatic hypotension.Scientific reports · 2025Article
- Artificial intelligence driven clustering of blood pressure profiles reveals frailty in orthostatic hypertension.Experimental physiology · 2025Article
- Identification of potentially causative drugs associated with hypotension: A scoping review.Archiv der Pharmazie · 2025Article
- Article
- Orthostatic hypotension and neurocognitive disorders in older women: Results from the EPIDOS cohort study.PloS one · 2023Article
- Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels.Annals of clinical and translational neurology · 2022Article
- Orthostatic hypotension is not associated with small vessel disease progression or cognitive decline.Cerebral circulation - cognition and behavior · 2021Review
- Early autonomic and cognitive dysfunction in PD, DLB and MSA: blurring the boundaries between α-synucleinopathies.Journal of neurology · 2020Article
- Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease.Journal of neurology · 2020Article
- Self-reported sleep disturbances are associated with poorer cognitive performance in older adults with hypertension: a multi-parameter risk factor investigation.International psychogeriatrics · 2020Article
- Cognitive Profile and Its Evolution in a Cohort of Multiple System Atrophy Patients.Frontiers in neurology · 2020Article
- Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland) · 2020Article
- Predictors of Orthostatic Hypotension in the Elderly: Results from the Amirkola Health and Ageing Project (AHAP) Study.The journal of Tehran Heart Center · 2019Article
- [Prevalence and relations of orthostatic hypotension in patients 80 years old and over from a primary care unit].Atencion primaria · 2019Observational
- Orthostatic hypotension and dementia incidence: links and implications.Neuropsychiatric disease and treatment · 2019Article
- Orthostatic hypotension acutely impairs executive functions in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Longitudinal and postural changes of blood pressure predict dementia: the Malmö Preventive Project.European journal of epidemiology · 2017Article
- Orthostatic Hypotension Predicts Cognitive Impairment in the Elderly: Findings from a Cohort Study.Frontiers in neurology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have addressed the relation between orthostatic hypotension (OH) and cognitive impairment (CI) in the elderly, in mild cognitive impairment, vascular and neurodegenerative dementias and movement disorders, such as Parkinson's disease. However, results concerning both the increased coexistence of the two conditions and their causal relationship remain controversial. According to the literature three hypotheses can be formulated on the relation between OH and CI. In neurodegenerative disease, OH and CI may result from a common pathological process which affects areas involved in both cognition and cardiovascular autonomic control. Alternatively, OH may lead to cerebral hypoperfusion which is supposed to play a role in the development of CI. Finally, recent data suggest that CI should probably be considered more a transient symptom of OH than a chronic effect. This study reviews the literature reports on the relationship between OH and CI, and emphasises the need for longitudinal studies designed to investigate this topic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.