ArticleJournal of the Association for Research in Otolaryngology : JARO2014
Assessment of nutrient supplement to reduce gentamicin-induced ototoxicity.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Development and Preclinical Evaluation of Fixed-Dose Capsules Containing Nicergoline, Piracetam, and Hawthorn Extract for Sensorineural Hearing Loss.Pharmaceutics · 2025Article
- Effects of Methionine and Glutathione on Acute Ototoxicity Induced by Amikacin and Furosemide in an Animal Model of Hearing Threshold Decrease.Biomedicines · 2025Article
- Efficacy and Mechanisms of Antioxidant Compounds and Combinations Thereof against Cisplatin-Induced Hearing Loss in a Rat Model.Antioxidants (Basel, Switzerland) · 2024Article
- N-Acetyl-L-cysteine Affects Ototoxicity Evoked by Amikacin and Furosemide Either Alone or in Combination in a Mouse Model of Hearing Threshold Decrease.International journal of molecular sciences · 2023Article
- Antibiotic Therapy and Athletes: Is the Mitochondrial Dysfunction the Real Achilles' Heel?Sports (Basel, Switzerland) · 2022Review
- Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells.Journal of the Chinese Medical Association : JCMA · 2022Article
- Frailty Syndrome and Oxidative Stress as Possible Links Between Age-Related Hearing Loss and Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Advances in Inner Ear Therapeutics for Hearing Loss in Children.Current otorhinolaryngology reports · 2020Article
- Risk versus benefit: Should not audiologists assess this in the context of occupational noise-induced hearing loss in the mining industry?The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2020Review
- Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.The Journal of the Acoustical Society of America · 2019Review
- Otoprotectants: From Research to Clinical Application.Seminars in hearing · 2019Review
- Adverse outcome pathway for aminoglycoside ototoxicity in drug-resistant tuberculosis treatment.Archives of toxicology · 2019Article
- Structure Characterization and Otoprotective Effects of a New Endophytic Exopolysaccharide from Saffron.Molecules (Basel, Switzerland) · 2019Article
- Animal model studies yield translational solutions for cochlear drug delivery.Hearing research · 2018Review
- An Oral Combination of Vitamins A, C, E, and MgFrontiers in neuroscience · 2018Article
- Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.Journal of nephrology · 2017Article
- ACEMg Diet Supplement Modifies Progression of Hereditary Deafness.Scientific reports · 2016Article
- Sensorineural deafness following routine transurethral resection of the prostate.BMJ case reports · 2015Article
- The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line.Neurotoxicology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Gentamicin is an aminoglycoside antibiotic used to treat gram-negative bacterial infections. Treatment with this antibiotic carries the potential for adverse side effects, including ototoxicity and nephrotoxicity. Ototoxic effects are at least in part a consequence of oxidative stress, and various antioxidants have been used to attenuate gentamicin-induced hair cell death and hearing loss. Here, a combination of nutrients previously shown to reduce oxidative stress in the hair cells and attenuate hearing loss after other insults was evaluated for potential protection against gentamicin-induced ototoxicity. Guinea pigs were maintained on a nutritionally complete standard laboratory animal diet or a diet supplemented with β-carotene, vitamins C and E, and magnesium. Three diets with iterative increases in nutrient levels were screened; the final diet selected for study use was one that produced statistically reliable increases in plasma levels of vitamins C and E and magnesium. In two separate studies, significant decreases in gentamicin-induced hearing loss at frequencies including 12 kHz and below were observed, with less benefit at the higher frequencies. Consistent with the functional protection, robust protection of both the inner and outer hair cell populations was observed, with protection largely in the upper half of the cochlea. Protection was independently assessed in two different laboratories, using two different strains of guinea pigs. Additional in vitro tests did not reveal any decrease in antimicrobial activity with nutrient additives. Currently, there are no FDA-approved treatments for the prevention of gentamicin-induced ototoxicity. The current data provide a rationale for continued investigations regarding translation to human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.