Evidence map›Paper›PMID 24590387›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2014

Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers.

Nada O F Kassem, Reem M Daffa, Sandy Liles, Sheila R Jackson, Noura O Kassem, Maram A Younis, Setoo Mehta, Menglan Chen, Peyton Jacob, Steve G Carmella and 5 more

Abstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Thirdhand smoke: Genotoxicity and carcinogenic potential.Chronic diseases and translational medicine · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Waterpipe smoking: the pressing need for risk communication.Expert review of respiratory medicine · 2019
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nada O F KassemCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA; nadakassem@hotmail.com.
Reem M DaffaCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;
Sandy LilesCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;
Sheila R JacksonCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;
Noura O KassemCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;
Maram A YounisCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;
Setoo MehtaCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;
Menglan ChenMasonic Cancer Center, University of Minnesota, Minneapolis, MN;
Peyton JacobDepartments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA;
Steve G CarmellaMasonic Cancer Center, University of Minnesota, Minneapolis, MN;
Dale A ChatfieldDepartment of Chemistry, San Diego State University, San Diego, CA;
Neal L BenowitzDepartments of Medicine and Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA;
Georg E MattCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA; Department of Psychology, San Diego State University, San Diego, CA.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, MN;
Melbourne F HovellCenter for Behavioral Epidemiology and Community Health, Graduate School of Public Health, Division of Health Promotion, San Diego State University, San Diego, CA;

Funding

Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON, JONES, REESE T. · 1999 to 2024
$17.1M
METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESR01CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN S HECHT · 1999 to 2026
$7.1M
Metabolism of Carcinogenic Tobacco-Specific NitrosaminesR37CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2004 to 2013
$5.5M
Innovation for Smoke-Free Homes: Real-Time FeedbackR01HL103684 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI HOVELL, MELBOURNE F · 2011 to 2015
$5.4M
Clinician Promotion of Healthy Diet and Activity to Reduce Obesity Among AdolesceR01CA138192 · NCI · SAN DIEGO STATE UNIVERSITY · PI HOVELL, MELBOURNE F · 2009 to 2014
$4.0M
Liquid Chromatograph-Triple Quadrupole Mass SpectrometerS10RR026437 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON · 2010 to 2010
$448k
NCI NIH HHS CA-81301NCI NIH HHS R01 CA081301NCI NIH HHS R01 CA138192-01A1NCRR NIH HHS S10 RR026437NHLBI NIH HHS R01HL103684-01A1NIDA NIH HHS P30 DA012393
6 · The paper itself

Abstract

introductionWe examined homes of hookah-only smokers and nonsmokers for levels of indoor air nicotine (a marker of secondhand smoke) and indoor surface nicotine (a marker of thirdhand smoke), child uptake of nicotine, the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and the toxicant acrolein by analyzing their corresponding metabolites cotinine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and NNAL-glucuronides (total NNAL) and 3-hydroxypropylmercapturic acid.

methodsData were collected at 3 home visits during a 7-day study period from a convenience sample of 24 households with a child 5 years or younger. Three child urine samples and 2 air and surface samples from the living room and the child bedroom were taken in homes of nonsmokers (n = 5) and hookah-only smokers (n = 19) comprised of daily hookah smokers (n = 8) and weekly/monthly hookah smokers (n = 11).

resultsNicotine levels in indoor air and on surfaces in the child bedrooms in homes of daily hookah smokers were significantly higher than in homes of nonsmokers. Uptake of nicotine, NNK, and acrolein in children living in daily hookah smoker homes was significantly higher than in children living in nonsmoker homes. Uptake of nicotine and NNK in children living in weekly/monthly hookah smoker homes was significantly higher than in children living in nonsmoker homes.

conclusionsOur data provide the first evidence for uptake of nicotine, the tobacco-specific lung carcinogen NNK, and the ciliatoxic and cardiotoxic agent acrolein in children living in homes of hookah smokers. Our findings suggest that daily and occasional hookah use in homes present a serious, emerging threat to children's long-term health.

Indexed as

HousingSmokingAcetylcysteineAirBiomarkersCarcinogensChild, PreschoolCotinineCross-Sectional StudiesEnvironmental ExposureFamily CharacteristicsFemaleHumansMaleNicotineNitrosamines4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneAcetylcysteineBiomarkersCarcinogensCotinineNicotineNitrosaminesPyridinesS-(3-hydroxypropyl)cysteine N-acetateTobacco Smoke Pollution

Identifiers

PMID24590387
PMCPMC4072898

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.