ArticleClinical and experimental nephrology2015
Serum renalase is related to catecholamine levels and renal function.
Article in Clinical and experimental nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Assay-dependent variability in peptide biomarker quantification: experimental evidence from renalase in chronic kidney disease.Annals of medicine · 2026Article
- Renalase, dopamine, and norepinephrine as markers for the development of hypertension in CKD patients.BMC nephrology · 2025Article
- Review
- Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2022Article
- Review
- Circulating Renalase as Predictor of Renal and Cardiovascular Outcomes in Pre-Dialysis CKD Patients: A 5-Year Prospective Cohort Study.Life (Basel, Switzerland) · 2021Article
- Renalase in Haemodialysis Patients with Chronic Kidney Disease.Journal of clinical medicine · 2021Article
- Moderate-intensity exercise increases renalase levels in the blood and skeletal muscle of rats.FEBS open bio · 2020Article
- A Novel Biomarker Renalase and Its Relationship with its Substrates in Schizophrenia.Journal of medical biochemistry · 2019Article
- Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease.The Korean journal of internal medicine · 2019Article
- Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients.PloS one · 2017Article
- Limb ischemic preconditioning protects against contrast-induced nephropathy via renalase.EBioMedicine · 2016Article
- Online Haemodiafiltration Improves Inflammatory State in Dialysis Patients: A Longitudinal Study.PloS one · 2016Article
- Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α.Journal of cellular and molecular medicine · 2015Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenalase is a kidney-origin monoamine oxidase which can degrade catecholamines and regulate blood pressure and cardiovascular function. Although it has been shown that serum renalase level significantly decreases with impaired renal function, it is not clear whether its level is related to different stages of chronic kidney disease (CKD) in patients.
methodsEighty-seven patients with CKD were selected as subjects of this study to investigate the serum renalase and catecholamine (CA) levels by ELISA method, and their relationship with other renal function indicators.
resultsSerum levels of renalase and renalase-catecholamine (R/C) ratios were significantly higher in CKD stage 3-5 patients (217.4 ± 103.8 ng/L, 1.00 ± 0.21) than CKD stage 1-2 patients (162.1 ± 40.1 ng/L, 0.82 ± 0.16; P < 0.05), while there was no significant difference between CKD stage 1-2 patients and the normal control group (167.8 ± 69.4 ng/L, 0.88 ± 0.17; P > 0.05). Renalase levels were linearly correlated with catecholamine levels (R (2) = 0.817; P < 0.01). Serum renalase levels were positively correlated with systolic blood pressure (SBP), serum CA, BUN, SCr, UA, and CKD stage (P < 0.05), while negatively correlated with RBC, Hb and estimated GFR (eGFR) (P < 0.05). R/C ratio was positively correlated with SBP, diastolic blood pressure, BUN, SCr, UA, cystatin C, β2 microglobulin, retinol binding protein-4 and CKD stage (P < 0.05), while negatively correlated with RBC, Hb, eGFR and GFR (P < 0.05).
conclusionsSerum levels of renalase are highly correlated with CA and both serum renalase levels and R/C ratios are related to renal function.
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