ArticleInternational journal of molecular sciences2014
Multilineage potential research of bovine amniotic fluid mesenchymal stem cells.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential.Animals : an open access journal from MDPI · 2025Review
- An Update on Applications of Cattle Mesenchymal Stromal Cells.Animals : an open access journal from MDPI · 2022Review
- Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species.Frontiers in cell and developmental biology · 2021Review
- Post-calving umbilical cord tissue offcut: A potential source for the isolation of bovine mesenchymal stem cells.Veterinary world · 2020Article
- Effect and mechanism of human umbilical cord mesenchymal stem cells in treating allergic rhinitis in mice.Scientific reports · 2020Article
- Mesenchymal stem cells promote glioma neovascularization in vivo by fusing with cancer stem cells.BMC cancer · 2019Article
- Applications of mesenchymal stem cell technology in bovine species.Stem cell research & therapy · 2019Review
- Multilineage potential research of Beijing duck amniotic mesenchymal stem cells.Cell and tissue banking · 2018Article
- Isolation, culture, and characterization of chicken lung-derived mesenchymal stem cells.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Article
- Isolation and characterization of buffalo (bubalus bubalis) amniotic mesenchymal stem cells derived from amnion from the first trimester pregnancy.The Journal of veterinary medical science · 2018Article
- Biological characterization of sheep kidney-derived mesenchymal stem cells.Experimental and therapeutic medicine · 2016Article
- Article
- The treatment of articular cartilage injuries with mesenchymal stem cells in different animal species.Open veterinary journalReview
- Effect of Intra-ovarian Injection of Mesenchymal Stem Cells or its Conditioned Media on Repeated OPU-IVEP Outcomes in Jersey Heifers and Its Relationship with Follicular Fluid Inflammatory Markers.Avicenna journal of medical biotechnologyArticle
- Phenotypic and Cytogenetic Characterization of Mesenchymal Stromal Cells inAnalytical cellular pathology (Amsterdam)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of amnion and amniotic fluid (AF) are abundant sources of mesenchymal stem cells (MSCs) that can be harvested at low cost and do not pose ethical conflicts. In human and veterinary research, stem cells derived from these tissues are promising candidates for disease treatment, specifically for their plasticity, their reduced immunogenicity, and high anti-inflammatory potential. This work aimed to obtain and characterize bovine amniotic fluid mesenchymal stem cells (AFMSC). The bovine AF from the amniotic cavity of pregnant gilts in the early stages of gestation (3- and 4-m-old bovine embryos) was collected. AFMSCs exhibit a fibroblastic-like morphology only starting from the fourth passage, being heterogeneous during the primary culture. Immunofluorescence results showed that AFMSCs were positive for β-integrin, CD44, CD73 and CD166, but negative for CD34, CD45. Meanwhile, AFMSCs expressed ES cell markers, such as Oct4, and when appropriately induced, are capable of differentiating into ectodermal and mesodermal lineages. This study reinforces the emerging importance of these cells as ideal tools in veterinary medicine; future studies aimed at a deeper evaluation of their immunological properties will allow a better understanding of their role in cellular therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.