ArticleJournal of biomedical optics2014
Integrated photoacoustic, confocal, and two-photon microscope.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Photoacoustic and fluorescence hybrid microscope for cortex-wide imaging of neurovascular dynamics with subcellular resolution.Science advances · 2025Article
- Integrated two-photon and optoacoustic microscopy for functional neuroimaging.Scientific reports · 2025Article
- Simultaneous head-mounted imaging of neural and hemodynamic activities at high spatiotemporal resolution in freely behaving mice.Science advances · 2025Article
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- The emerging role of photoacoustic imaging in clinical oncology.Nature reviews. Clinical oncology · 2022Review
- Review on Optical Imaging Techniques for Multispectral Analysis of Nanomaterials.Nanotheranostics · 2022Review
- Indocyanine green dye based bimodal contrast agent tested by photoacoustic/fluorescence tomography setup.Biomedical optics express · 2021Article
- Integrating photoacoustic microscopy with other imaging technologies for multimodal imaging.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Pushing the boundaries of optoacoustic microscopy by total impulse response characterization.Nature communications · 2020Article
- Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae.Biomedical optics express · 2020Article
- The integrated high-resolution reflection-mode photoacoustic and fluorescence confocal microscopy.Photoacoustics · 2019Article
- Simultaneous ultra-high frequency photoacoustic microscopy and photoacoustic radiometry of zebrafish larvaePhotoacoustics · 2018Article
- Performance of optoacoustic and fluorescence imaging in detecting deep-seated fluorescent agents.Biomedical optics express · 2018Article
- Advanced optoacoustic methods for multiscale imaging of in vivo dynamics.Chemical Society reviews · 2017Review
- Multimodal optoacoustic and multiphoton microscopy of human carotid atheroma.Photoacoustics · 2016Article
- Fully integrated reflection-mode photoacoustic, two-photon, and second harmonic generation microscopy in vivo.Scientific reports · 2016Article
- Multiscale Functional and Molecular Photoacoustic Tomography.Ultrasonic imaging · 2016Review
- Combining microscopy with mesoscopy using optical and optoacoustic label-free modes.Scientific reports · 2015Article
- Photoacoustic imaging platforms for multimodal imaging.Ultrasonography (Seoul, Korea) · 2015Review
- Isometric multimodal photoacoustic microscopy based on optically transparent micro-ring ultrasonic detection.Optica · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The invention of green fluorescent protein and other molecular fluorescent probes has promoted applications of confocal and two-photon fluorescence microscopy in biology and medicine. However, exogenous fluorescence contrast agents may affect cellular structure and function, and fluorescence microscopy cannot image nonfluorescent chromophores. We overcome this limitation by integrating optical-resolution photoacoustic microscopy into a modern Olympus IX81 confocal, two-photon, fluorescence microscope setup to provide complementary, label-free, optical absorption contrast. Automatically coregistered images can be generated from the same sample. Imaging applications in ophthalmology, developmental biology, and plant science are demonstrated. For the first time, in a familiar microscopic fluorescence imaging setting, this trimodality microscope provides a platform for future biological and medical discoveries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.