Evidence map›Paper›PMID 24589977›Full record

ReviewBiochimica et biophysica acta2014

Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Guillaume Bergthold, Pratiti Bandopadhayay, Wenya Linda Bi, Lori Ramkissoon, Charles Stiles, Rosalind A Segal, Rameen Beroukhim, Keith L Ligon, Jacques Grill, Mark W Kieran

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Pediatric low-grade glioma in the era of molecular diagnostics.Acta neuropathologica communications · 2020
    Review
  14. Review
  15. Article
  16. Review
  17. [Effect of bevacizumab in treatment of children with optic pathway glioma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Article
  18. Telomere Maintenance in Pediatric Cancer.International journal of molecular sciences · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guillaume BergtholdDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Pratiti BandopadhayayDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Boston Children's Hospital, Boston, MA, USA.
Wenya Linda BiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Lori RamkissoonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Charles StilesDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Rosalind A SegalDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Rameen BeroukhimDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Keith L LigonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jacques GrillDepartement de Cancerologie de l'enfant et de l'adolescent, Gustave Roussy and Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Sud, Villejuif, France.
Mark W KieranCenter for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: mark_kieran@dfci.harvard.edu.

Funding

Transcriptional control of inhibitory synapse formationP01NS047572 · NINDS · DANA-FARBER CANCER INSTITUTE · PI MA, QIUFU · 2004 to 2013
$13.5M
Therapeutic Opportunities for Pediatric AstrocytomaP01CA142536 · NCI · DANA-FARBER CANCER INST · PI LIGON, KEITH LLOYD · 2011 to 2015
$7.9M
NCI NIH HHS P01 CA142536NCI NIH HHS P01CA142536NINDS NIH HHS P01 NS047572NINDS NIH HHS P01NS047572
6 · The paper itself

Abstract

Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.

Indexed as

ApoptosisBrain NeoplasmsCell SurvivalEpigenesis, GeneticGliomaHumansMolecular Targeted TherapyNeoplasm GradingPediatricsPrognosisBRAFGeneticsLow-grade gliomaPediatric

Identifiers

PMID24589977
PMCPMC4082403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.