ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2014
Impact of initial tumor volume on radiotherapy outcome in patients with T2 glottic cancer.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta-analysis.Head & neck · 2021Pooled it
- Tumor volume as a prognostic factor of locally advanced laryngeal cancer.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Primary tumor volume as a predictor of distant metastases and survival in patients with sinonasal mucosal melanoma.Head & neck · 2020Article
- Tumor Volumes and Prognosis in Laryngeal Cancer.Cancers · 2015Article
- The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer.Contemporary oncology (Poznan, Poland) · 2014Article
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Abstract
backgroundThe aim of this study was to quantify the impact of initial tumor volume (TV) on radiotherapy (RT) outcome in patients with T2 glottic cancer. MATERIALS AND
methodsInitial TV was calculated for 115 consecutive patients with T2 glottic cancer who had been treated with definitive RT alone at a single institution.
resultsThe results showed strong correlations of TV with 3-year local tumor control (LTC) and disease-free survival (DFS). For TV ≤ 0.7 cm(3), 3-year LTC was 83%; for TV 0.7-3.6 cm(3) this was 70% and for TV 3.6-17 cm(3) 44%. Analysis of total dose vs. initial TV showed that larger T2 glottic tumors with a TV of around 5 cm(3) (2-2.5 cm in diameter with 10(10) cancer cells) need an extra 6.5 Gy to achieve similar 3-year LTC rates as for small tumors with a TV of 0.5 cm(3) (~1 cm in diameter with 10(9) cancer cells).
conclusionAlthough classification of tumors according to TV cannot replace TNM staging in daily practice, it could represent a valuable numerical supplement for planning the optimal dose fractionation scheme for individual patients.
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