ReviewThe pharmacogenomics journal2014
Gene expression analysis in RA: towards personalized medicine.
Review in The pharmacogenomics journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome uncovered through gene expression meta-analysis.Arthritis research & therapy · 2014Pooled it
- Role of sRAGE in clinical heterogeneity and inflammation in endometriosis patients undergoing IVF; case-control study.BMC endocrine disorders · 2026Article
- Blood-based gene signatures associated with therapeutic response to anti-TNF therapy in rheumatoid arthritis: a combined meta-analytical and machine learning approach.EULAR rheumatology open · 2026Article
- N-of-one differential gene expression without control samples using a deep generative model.Genome biology · 2023Article
- New Insights and Potential Therapeutic Interventions in Metabolic Diseases.International journal of molecular sciences · 2023Review
- A systems biology approach for investigating significantly expressed genes among COVID-19, hepatocellular carcinoma, and chronic hepatitis B.The Egyptian journal of medical human genetics · 2022Article
- A Method to Pre-Screen Rat Mammary Gland Whole-Mounts Prior To RNAscope.Journal of mammary gland biology and neoplasia · 2021Article
- Development of a Four-mRNA Expression-Based Prognostic Signature for Cutaneous Melanoma.Frontiers in genetics · 2021Article
- Development of a Prognostic Five-Gene Signature for Diffuse Lower-Grade Glioma Patients.Frontiers in neurology · 2021Article
- Prognostic Value of an Autophagy-Related Five-Gene Signature for Lower-Grade Glioma Patients.Frontiers in oncology · 2021Article
- An integrative transcriptome analysis framework for drug efficacy and similarity reveals drug-specific signatures of anti-TNF treatment in a mouse model of inflammatory polyarthritis.PLoS computational biology · 2019Article
- Compendium of synovial signatures identifies pathologic characteristics for predicting treatment response in rheumatoid arthritis patients.Clinical immunology (Orlando, Fla.) · 2019Article
- Efficacy of Integrating a Novel 16-Gene Biomarker Panel and Intelligence Classifiers for Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis.Journal of clinical medicine · 2019Article
- Liquid biopsies to guide therapeutic decisions in rheumatoid arthritis.Translational research : the journal of laboratory and clinical medicine · 2018Review
- Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis.Arthritis research & therapy · 2018Article
- Principles and methods of in-silico prioritization of non-coding regulatory variants.Human genetics · 2018Review
- Rheumatoid Arthritis: A Brief Overview of the Treatment.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Review
- Current and future trends in Russian Rheumatology Care and Research.Mediterranean journal of rheumatology · 2017Review
- Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?Arthritis research & therapy · 2017Review
- Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis.Rheumatology international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression has recently been at the forefront of advance in personalized medicine, notably in the field of cancer and transplantation, providing a rational for a similar approach in rheumatoid arthritis (RA). RA is a prototypic inflammatory autoimmune disease with a poorly understood etiopathogenesis. Inflammation is the main feature of RA; however, many biological processes are involved at different stages of the disease. Gene expression signatures offer management tools to meet the current needs for personalization of RA patients' care. This review analyses currently available information with respect to RA diagnostic, prognostic and prediction of response to therapy with a view to highlight the abundance of data, whose comparison is often inconclusive due to the mixed use of material source, experimental methodologies and analysis tools, reinforcing the need for harmonization if gene expression signatures are to become a useful clinical tool in personalized medicine for RA patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.