ReviewMedizinische Klinik, Intensivmedizin und Notfallmedizin2014
[The golden hour of sepsis: initial therapy should start in the prehospital setting].
Review in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- MALDI-TOF mass spectrometry rapid pathogen identification and outcomes of patients with bloodstream infection: A systematic review and meta-analysis.Microbial biotechnology · 2022Pooled it
- Cannabinoids in preclinical research of sepsis: a scoping review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Non-Traumatic Abdominal Pain.Deutsches Arzteblatt international · 2023Article
- [Sepsis in out-of-hospital emergency medicine].Notfall & rettungsmedizin · 2022Review
- Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival.Critical care (London, England) · 2018Article
- Barriers to Accessing Emergency Medical Services in Accra, Ghana: Development of a Survey Instrument and Initial Application in Ghana.Global health, science and practice · 2015Article
- Decreased serum concentrations of sphingosine-1-phosphate in sepsis.Critical care (London, England) · 2015Article
- Magnetically-actuated, bead-enhanced silicon photonic immunosensor.Analytical methods : advancing methods and applications · 2015Article
- Ambulance use in Pakistan: an analysis of surveillance data from emergency departments in Pakistan.BMC emergency medicine · 2015Article
- [Early goal directed therapy in severe sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Review
- [First-line anti-infective treatment in sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a common, time-urgent emergency that is still associated with a high mortality and morbidity rate. A strong correlation between the onset of therapy and survival has been shown. With every hour of delay, survival decreases by 7.6 %. In 2001, four treatment goals that should be performed in the first 6 h of treatment were developed. These form the basis of early goal-directed therapy (EDGT) which is accepted as the standard of treatment for sepsis in the emergency department.
objectivesMore than half of patients are admitted to the hospital by medical emergency services. Up to 40 % receive prehospital therapy with i.v. fluids and stabilization of vital signs according to the goals of EDGT. The diagnosis of sepsis is difficult if characteristic symptoms or parameters such as in the ST segment elevation myocardial infarction are lacking. However, 90 % of patients present with fever.
conclusionsBody temperature should always be assessed by paramedics. In addition, sepsis must always be considered as part of the differential diagnosis. If the suspicion cannot be ruled out, immediate therapy has to be initiated. Concerning the prehospital use of antibiotics, preliminary results of a study from the center of sepsis control and care in Jena, Germany, showed that this therapy form seems to be safe and effective, but further evaluation is necessary.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.