ReviewGenes & development2014
Small but sturdy: small RNAs in cellular memory and epigenetics.
Review in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation.Diagnostics (Basel, Switzerland) · 2025Review
- The role of microbial partners in heavy metal metabolism in plants: a review.Plant cell reports · 2024Review
- Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma.Cancer biomarkers : section A of Disease markers · 2024Article
- Epigenetics and the Exposome: DNA Methylation as a Proxy for Health Impacts of Prenatal Environmental Exposures.Exposome · 2023Article
- Article
- PIWI interacting RNAs perspectives: a new avenues in future cancer investigations.Bioengineered · 2021Review
- PIWI proteins and piRNAs in cervical cancer: a propitious dart in cancer stem cell-targeted therapy.Human cell · 2021Review
- LncRNA FENDRR Inhibits ox-LDL Induced Mitochondrial Energy Metabolism Disorder in Aortic Endothelial CellsFrontiers in endocrinology · 2021Article
- Biopathological Significance of PIWI-piRNA Pathway Deregulation in Invasive Breast Carcinomas.Cancers · 2020Article
- Epigenomics and gene regulation in mammalian social systems.Current zoology · 2020Article
- PIWI-interacting RNAs: new biomarkers for diagnosis and treatment of breast cancer.Cell & bioscience · 2020Review
- Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs.Cells · 2019Review
- Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations inGenetics · 2018Article
- The Vast Complexity of the Epigenetic Landscape during Neurodevelopment: An Open Frame to Understanding Brain Function.International journal of molecular sciences · 2018Review
- Levels of DNA cytosine methylation in thePeerJ · 2018Article
- Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process.Frontiers in pharmacology · 2018Article
- An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation.Oncotarget · 2016Article
- Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.Molecular metabolism · 2016Article
- Decoding Lamarck-transgenerational control of metabolism by noncoding RNAs.Pflugers Archiv : European journal of physiology · 2016Review
- Transgenerational plasticity is sex-dependent and persistent in yellow monkeyflower (Environmental epigenetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cells in multicellular organisms have distinct identities characterized by their profiles of expressed genes. Cell identities can be stable over a long time and through multiple cellular divisions but are also responsive to extracellular signals. Since the DNA sequence is identical in all cells, a "cellular memory" of expression profiles is achieved by what are defined as epigenetic mechanisms. Two major molecular principles--networks of transcription factors and maintenance of cis-chromatin modifications--have been implicated in maintaining cellular memory. Here we describe recent studies demonstrating that short noncoding RNAs can also provide molecular signals that define epigenetic states of cells. Small RNAs can act independently or cooperate with chromatin modifications to achieve long-lasting effects necessary for cellular memory and transgenerational inheritance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.