ArticleBMC genomics2014
A new subfamily LIP of the major intrinsic proteins.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Structural and functional characterization of aquaporin 4 from the freshwater gastropod Pomacea canaliculata under temperature stress.Molecular biology reports · 2026Article
- Major Intrinsic Proteins in Fungi: A Special Emphasis on the XIP Subfamily.Journal of fungi (Basel, Switzerland) · 2025Review
- Early Diversification of Membrane Intrinsic Proteins (MIPs) in Eukaryotes.Genome biology and evolution · 2024Article
- From Homeostasis to Pathology: Decoding the Multifaceted Impact of Aquaporins in the Central Nervous System.International journal of molecular sciences · 2023Review
- Diversification of the aquaporin family in geographical isolated oyster species promote the adaptability to dynamic environments.BMC genomics · 2022Article
- Genome-Wide Identification, Structure Characterization, and Expression Pattern Profiling of the Aquaporin Gene Family inInternational journal of molecular sciences · 2021Article
- Article
- Genome Wild Analysis and Molecular Understanding of the Aquaporin Diversity in Olive Trees (International journal of molecular sciences · 2020Article
- De novo transcriptome assembly and analysis of the freshwater araphid diatom Fragilaria radians, Lake Baikal.Scientific data · 2019Article
- Combining genome-wide and transcriptome-wide analyses reveal the evolutionary conservation and functional diversity of aquaporins in cotton.BMC genomics · 2019Article
- Plasma Membrane-Type Aquaporins from Marine Diatoms Function as COPlant physiology · 2018Article
- Plant and Mammal Aquaporins: Same but Different.International journal of molecular sciences · 2018Review
- Molecular cloning and expression analysis of major intrinsic protein gene in Chlamydomonas sp. ICE-L from Antarctica.Extremophiles : life under extreme conditions · 2017Article
- Digital Gene Expression Analysis of Ponkan Mandarin (Citrus reticulata Blanco) in Response to Asia Citrus Psyllid-Vectored Huanglongbing Infection.International journal of molecular sciences · 2016Article
- Profiling gene expression in citrus fruit calyx abscission zone (AZ-C) treated with ethylene.Molecular genetics and genomics : MGG · 2015Article
- Sequencing of the complete genome of an araphid pennate diatom Synedra acus subsp. radians from Lake Baikal.Doklady. Biochemistry and biophysics · 2015Article
- Molecular Characterization of LRB7 Gene and a Water Channel Protein TIP2 inBioMed research internationalArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProteins of the major intrinsic protein (MIP) family, or aquaporins, have been detected in almost all organisms. These proteins are important in cells and organisms because they allow for passive transmembrane transport of water and other small, uncharged polar molecules.
resultsWe compared the predicted amino acid sequences of 20 MIPs from several algae species of the phylum Heterokontophyta (Kingdom Chromista) with the sequences of MIPs from other organisms. Multiple sequence alignments revealed motifs that were homologous to functionally important NPA motifs and the so-called ar/R-selective filter of glyceroporins and aquaporins. The MIP sequences of the studied chromists fell into several clusters that belonged to different groups of MIPs from a wide variety of organisms from different Kingdoms. Two of these proteins belong to Plasma membrane intrinsic proteins (PIPs), four of them belong to GlpF-like intrinsic proteins (GIPs), and one of them belongs to a specific MIPE subfamily from green algae. Three proteins belong to the unclassified MIPs, two of which are of bacterial origin. Eight of the studied MIPs contain an NPM-motif in place of the second conserved NPA-motif typical of the majority of MIPs. The MIPs of heterokonts within all detected clusters can differ from other MIPs in the same cluster regarding the structure of the ar/R-selective filter and other generally conserved motifs.
conclusionsWe proposed placing nine MIPs from heterokonts into a new group, which we have named the LIPs (large intrinsic proteins). The possible substrate specificities of the studied MIPs are discussed.
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