Evidence map›Paper›PMID 24589272›Full record

ReviewHematology/oncology clinics of North America2014

Modulators of erythropoiesis: emerging therapies for hemoglobinopathies and disorders of red cell production.

Laura Breda, Stefano Rivella

Abstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. The Influence of Inflammation on Anemia in CKD Patients.International journal of molecular sciences · 2020
    Review
  4. Review
  5. Review
  6. The Red Blood Cells on the Move!Frontiers in physiology · 2018
    Article
  7. How we manage iron overload in sickle cell patients.British journal of haematology · 2017
    Review
  8. β-Thalassemia.Genetics in medicine : official journal of the American College of Medical Genetics · 2017
    Review
  9. Article
  10. Review
  11. Review
  12. Iron age: novel targets for iron overload.Hematology. American Society of Hematology. Education Program · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laura BredaDepartment of Pediatrics, Hematology-Oncology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA. Electronic address: lab2002@med.cornell.edu.
Stefano RivellaDepartment of Pediatrics, Hematology-Oncology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA.
Cornell University · US

Funding

Regulatory Role of Transferrin in Erythropoiesis and Iron MetabolismR01DK095112 · NIDDK · SAINT LOUIS UNIVERSITY · PI Robert E Fleming, Yelena Ginzburg · 2012 to 2026
$5.4M
Hepcidin therapy for iron overload and hematologic disordersR01DK090554 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2021
$5.2M
The influence of genotype on the outcome of gene transfer in beta-thalassemiaR01HL102449 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2014
$2.1M
NHLBI NIH HHS R01 HL102449NIDDK NIH HHS R01 DK090554NIDDK NIH HHS R01 DK095112
6 · The paper itself

Abstract

Use of new compound such as inhibitors of JAK2 or transforming growth factor β-like molecules might soon revolutionize the treatment of β-thalassemia and related disorders. However, this situation requires careful optimization, noting the potential for off-target immune suppression for JAK2 inhibitors and the lack of mechanistic insights for the use of the ligand trap soluble molecules that sequester ligands of activin receptor IIA and B.

Indexed as

beta-ThalassemiaErythrocytesErythropoiesisHemoglobinopathiesActivin Receptors, Type IIHumansImmunoglobulin Fc FragmentsJanus Kinase 2Molecular Targeted TherapyRecombinant Fusion ProteinsActivin Receptors, Type IIImmunoglobulin Fc FragmentsJanus Kinase 2luspaterceptRecombinant Fusion ProteinssotaterceptACE-011ACE-536HemoglobinopathiesJAK2LY-2157299Steady stateStress and ineffective erythropoiesisTransforming growth factor β

Identifiers

PMID24589272
PMCPMC3970239
OpenAlexW124140964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.