Evidence map›Paper›PMID 24589027›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2014

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET).

C A Kauffman, A G Freifeld, D R Andes, J W Baddley, L Herwaldt, R C Walker, B D Alexander, E J Anaissie, K Benedict, J I Ito and 9 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.

  1. Pooled it
  2. Prognosis of Patients Infected WithJournal of general and family medicine · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Updates on Donor-Derived Infection in Solid Organ Transplantation, Report from the 2024 GTI (Infection and Transplantation Group) Annual Meeting.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  7. Blastomycosis in a Renal Transplant Recipient: A Rare Encounter in Rural Appalachia.Journal of community hospital internal medicine perspectives · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Aspergillus and the Lung.Seminars in respiratory and critical care medicine · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Fungal infections in lung transplantation.Journal of thoracic disease · 2021
    Review
  16. Fungal Infections in Liver Transplant Recipients.Journal of fungi (Basel, Switzerland) · 2021
    Review
  17. Microbial Air Quality in Healthcare Facilities.International journal of environmental research and public health · 2021
    Review
  18. Clinical Manifestations and Outcomes in Immunocompetent and Immunocompromised Patients With Blastomycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 17 institutions in 1 country.

C A KauffmanUniversity of Michigan and Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.
A G Freifeld
D R Andes
J W Baddley
L Herwaldt
R C Walker
B D Alexander
E J Anaissie
K Benedict
J I Ito
K M Knapp
G M Lyon
K A Marr
V A Morrison
B J Park
T F Patterson
M G Schuster
T M Chiller
P G Pappas
Centers for Disease Control and Prevention · USBirmingham VA Medical Center · USCity of Hope · USDuke Medical Center · USEmory University · USFred Hutch Cancer Center · USMayo Clinic · USSouth Texas Veterans Health Care System · USSt. Jude Children's Research Hospital · USUniversity of Alabama at Birmingham · USUniversity of Arkansas for Medical Sciences · USUniversity of Iowa Hospitals and Clinics · USUniversity of Michigan–Ann Arbor · USUniversity of Minnesota Medical Center · USUniversity of Nebraska Medical Center · USUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · US

Funding

Transplant Associated Infection Surveillance NetworkU01CI000286 · CI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PAPPAS, PETER GEORGE · 2004 to 2008
$667k
Intramural CDC HHS CC999999NCPDCID CDC HHS 5U01CI000286-05NCPDCID CDC HHS U01 CI000286
6 · The paper itself

Abstract

backgroundInvasive fungal infections are a major cause of morbidity and mortality among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, but few data have been reported on the epidemiology of endemic fungal infections in these populations.

methodsFifteen institutions belonging to the Transplant-Associated Infection Surveillance Network prospectively enrolled SOT and HCT recipients with histoplasmosis, blastomycosis, or coccidioidomycosis occurring between March 2001 and March 2006.

resultsA total of 70 patients (64 SOT recipients and 6 HCT recipients) had infection with an endemic mycosis, including 52 with histoplasmosis, 9 with blastomycosis, and 9 with coccidioidomycosis. The 12-month cumulative incidence rate among SOT recipients for histoplasmosis was 0.102%. Occurrence of infection was bimodal; 28 (40%) infections occurred in the first 6 months post transplantation, and 24 (34%) occurred between 2 and 11 years post transplantation. Three patients were documented to have acquired infection from the donor organ. Seven SOT recipients with histoplasmosis and 3 with coccidioidomycosis died (16%); no HCT recipient died.

conclusionsThis 5-year multicenter prospective surveillance study found that endemic mycoses occur uncommonly in SOT and HCT recipients, and that the period at risk extends for years after transplantation.

Indexed as

Endemic DiseasesAdolescentAdultAgedAmphotericin BAntifungal AgentsBlastomycosisChildCoccidioidomycosisCoinfectionComorbidityFemaleHematopoietic Stem Cell TransplantationHistoplasmosisHumansIncidenceAmphotericin BAntifungal AgentsItraconazoleblastomycosiscoccidioidomycosishematopoietic cell transplanthistoplasmosissolid organ transplant

Identifiers

PMID24589027
PMCPMC5664161
OpenAlexW2066460729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.