ArticleBMC complementary and alternative medicine2014
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Review on recent advancements in understanding acetylsalicylic acid-induced gastrointestinal injury: mechanisms, medication, and dosage refinement.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The Landscape of Smart Biomaterial-Based Hydrogen Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Health Benefits of Electrolyzed Hydrogen Water: Antioxidant and Anti-Inflammatory Effects in Living Organisms.Antioxidants (Basel, Switzerland) · 2024Review
- Electrolyzed-Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects.International journal of molecular sciences · 2022Review
- Article
- Electrolyzed Oxidizing Water and Its Applications as Sanitation and Cleaning Agent.Food engineering reviews · 2021Review
- Effects of Electrolyzed Water on the Growth of Oral Pathologic Bacteria Species and its Cytotoxic Effects on Fibroblast and Epithelial Cells at Different pH Values.Iranian journal of medical sciences · 2020Article
- Effects of electrolyzed hydrogen water ingestion during endurance exercise in a heated environment on body fluid balance and exercise performance.Temperature (Austin, Tex.) · 2020Article
- Article
- The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats.Journal of radiation research · 2019Article
- Review
- Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.Medical gas research · 2015Article
- Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice.Medical gas researchArticle
- The transfer of hydrogen from inert gas to therapeutic gas.Medical gas researchReview
- Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms.Medical gas researchArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHydrogen has been reported to relieve damage in many disease models, and is a potential additive in drinking water to provide protective effects for patients as several clinical studies revealed. However, the absence of a dose-response relationship in the application of hydrogen is puzzling. We attempted to identify the dose-response relationship of hydrogen in alkaline electrolyzed drinking water through the aspirin induced gastric injury model.
methodsIn this study, hydrogen-rich alkaline water was obtained by adding H2 to electrolyzed water at one atmosphere pressure. After 2 weeks of drinking, we detected the gastric mucosal damage together with MPO, MDA and 8-OHdG in rat aspirin induced gastric injury model.
resultsHydrogen-dose dependent inhibition was observed in stomach mucosal. Under pH 8.5, 0.07, 0.22 and 0.84 ppm hydrogen exhibited a high correlation with inhibitory effects showed by erosion area, MPO activity and MDA content in the stomach. Gastric histology also demonstrated the inhibition of damage by hydrogen-rich alkaline water. However, 8-OHdG level in serum did not have significant hydrogen-dose dependent effect. pH 9.5 showed higher but not significant inhibitory response compared with pH 8.5.
conclusionsHydrogen is effective in relieving the gastric injury induced by aspirin-HCl, and the inhibitory effect is dose-dependent. The reason behind this may be that hydrogen-rich water directly interacted with the target tissue, while the hydrogen concentration in blood was buffered by liver glycogen, evoking a suppressed dose-response effect. Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.
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