ArticleAntimicrobial resistance and infection control2014
Increased EMRSA-15 health-care worker colonization demonstrated in retrospective review of EMRSA hospital outbreaks.
Article in Antimicrobial resistance and infection control, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Linking chemical-composition to antimicrobial efficacy: development of an essential oil-based topical gel prototype.Applied microbiology and biotechnology · 2025Article
- Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections.Antibiotics (Basel, Switzerland) · 2021Article
- Genomic Analysis of Multiresistant Staphylococcus capitis Associated with Neonatal Sepsis.Antimicrobial agents and chemotherapy · 2018Article
- Healthcare-associated transmission of Panton-Valentine leucocidin positive methicillin-resistant Staphylococcus aureus: the value of screening asymptomatic healthcare workers.BMC infectious diseases · 2018Article
- Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing.PloS one · 2018Article
- Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.PloS one · 2017Article
- Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Isolated from Australian Veterinarians.PloS one · 2016Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundHealth care worker (HCW) colonization with methicillin resistant Staphylococcus aureus (MRSA) is a documented cause of hospital outbreaks and contributes to ongoing transmission. At Royal Perth Hospital (RPH) it had been anecdotally noted that the increasing prevalence of EMRSA-15 appeared to be associated with increased HCW colonization compared with Aus2/3-EMRSA. Hence we compared HCW colonization rates during outbreaks of EMRSA-15 and Aus2/3-EMRSA at a single institution.
methodsWe performed a retrospective review of EMRSA-15 and Aus2/3-EMRSA outbreaks from 2000-2009 at RPH, a quaternary hospital in Western Australia. Outbreak files were reviewed and relevant data extracted.
resultsTen EMRSA-15 outbreaks were compared with seven Aus2/3 outbreaks. The number of patients colonized was similar between EMRSA-15 and Aus2/3-EMRSA outbreaks (median 7 [range 3-20] and 11 [5-26], respectively; P = 0.07) but the number of HCWs colonized was significantly higher in EMRSA-15 outbreaks compared to Aus2/3-EMRSA outbreaks (median 4 [range 0-15] and 2 [1-3], respectively; P = 0.013). The percentage of HCWs colonized was also higher in EMRSA-15 outbreaks versus Aus2/3-EMRSA outbreaks (median 3.4% [range 0-5.5%] and 0.81% [0.56-2.2%], respectively; P = 0.013).
conclusionsThis study demonstrates a higher level of HCW colonization during EMRSA-15 outbreaks compared with Aus2/3-EMRSA outbreaks. This finding suggests that MRSA vary in their ability to colonize HCWs and contribute to outbreaks. MRSA type should be determined during outbreaks and future research should investigate the mechanisms by which EMRSA-15 contributes to increased HCW colonization.
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