ArticleThe Journal of chemical physics2014
Interplay between chain stiffness and excluded volume of semiflexible polymers confined in nanochannels.
Article in The Journal of chemical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Macromolecule crowding effects on the phase separation of semi-flexible polymer in spherical confined space.Journal of biological physics · 2020Article
- Conformation of Flexible and Semiflexible Chains Confined in Nanoposts Array of Various Geometries.Polymers · 2020Article
- Extension distribution for DNA confined in a nanochannel near the Odijk regime.The Journal of chemical physics · 2019Article
- Measuring the wall depletion length of nanoconfined DNA.The Journal of chemical physics · 2018Article
- Motor-like DNA motion due to an ATP-hydrolyzing protein under nanoconfinement.Scientific reports · 2018Article
- Evidence for the extended de Gennes regime of a semiflexible polymer in slit confinement.Physical review. E · 2018Article
- Article
- Simulations of knotting of DNA during genome mapping.Biomicrofluidics · 2017Article
- Modeling the relaxation of internal DNA segments during genome mapping in nanochannels.Biomicrofluidics · 2016Article
- The Backfolded Odijk Regime for Wormlike Chains Confined in Rectangular Nanochannels.Polymers · 2016Article
- Finite-size corrections for confined polymers in the extended de Gennes regime.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Article
- Experimental evidence of weak excluded volume effects for nanochannel confined DNA.ACS macro letters · 2015Article
- Kirkwood diffusivity of long semiflexible chains in nanochannel confinement.Macromolecules · 2015Article
- Distribution of distances between DNA barcode labels in nanochannels close to the persistence length.The Journal of chemical physics · 2015Article
- Hydrodynamics of DNA confined in nanoslits and nanochannels.The European physical journal. Special topics · 2014Article
- Mixed confinement regimes during equilibrium confinement spectroscopy of DNA.The Journal of chemical physics · 2014Article
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4 authors.
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Abstract
The properties of channel-confined semiflexible polymers are determined by a complicated interplay of chain stiffness and excluded volume effects. Using Pruned-Enriched Rosenbluth Method (PERM) simulations, we study the equilibrium properties of channel-confined polymers by systematically controlling chain stiffness and excluded volume. Our calculations of chain extension and confinement free energy for freely jointed chains with and without excluded volume show excellent agreement with theoretical predictions. For ideal wormlike chains, the extension is seen to crossover from Odijk behavior in strong confinement to zero-stretching, bulk-like behavior in weak confinement. In contrast, for self-avoiding wormlike chains, we always observe that the linear scaling of the extension with the contour length is valid in the long-chain limit irrespective of the regime of confinement, owing to the coexistence of stiffness and excluded volume effects. We further propose that the long-chain limit for the extension corresponds to chain lengths wherein the projection of the end-to-end distance along the axis of the channel is nearly equal to the mean span parallel to the axis. For DNA in nanochannels, this limit was identified using PERM simulations out to molecular weights of more than 1 megabase pairs; the molecular weight of λ-DNA is found to exhibit nearly asymptotic fractional extension for channels sizes used commonly in experiments.
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