Evidence map›Paper›PMID 24587981›Full record

ArticleWorld journal of hypertension2012

Oxidative stress-mediated effects of angiotensin II in the cardiovascular system.

Hairuo Wen, Judith K Gwathmey, Lai-Hua Xie

Open access · hybridAbstract read
In one paragraph

Article in World journal of hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 106 citations in OpenAlex.

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  11. Effects of aurantiamide on a rat model of renovascular arterial hypertension.Pflugers Archiv : European journal of physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hairuo WenDepartment of Cell Biology and Molecular Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103, United States.
Judith K GwathmeyGwathmey Inc., Cambridge, MA 02138, United States.
Lai-Hua XieDepartment of Cell Biology and Molecular Medicine, UMDNJ-New Jersey Medical School, Newark, NJ 07103, United States.
Rutgers, The State University of New Jersey · US

Funding

Antiarrhythmic Mechanisms in the Hearts of Hibernating MammalsR01HL097979 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI XIE, LAI-HUA · 2010 to 2015
$1.9M
NHLBI NIH HHS R01 HL097979
6 · The paper itself

Abstract

Angiotensin II (Ang II), an endogenous peptide hormone, plays critical roles in the pathophysiological modulation of cardiovascular functions. Ang II is the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system, as well as a potent stimulator of NAD(P)H oxidase, which is the major source and primary trigger for reactive oxygen species (ROS) generation in various tissues. Recent accumulating evidence has demonstrated the importance of oxidative stress in Ang II-induced heart diseases. Here, we review the recent progress in the study on oxidative stress-mediated effects of Ang II in the cardiovascular system. In particular, the involvement of Ang II-induced ROS generation in arrhythmias, cell death/heart failure, ischemia/reperfusion injury, cardiac hypertrophy and hypertension are discussed. Ca

Indexed as

Angiotensin IIArrhythmiasHypertensionHypertrophyIschemia-reperfusionMitochondriaOxidative stress

Identifiers

PMID24587981
PMCPMC3936474
OpenAlexW2004854463

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.