ReviewMultiple sclerosis international2014
Gray matters in multiple sclerosis: cognitive impairment and structural MRI.
Review in Multiple sclerosis international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- The use of routinely collected structural neuroimaging to identify cognitive impairment in multiple sclerosis.BMC neurology · 2026Article
- Cognitive functioning in multiple sclerosis with focus on brainstem volume.Acta neurologica Belgica · 2026Article
- Brain Atrophy and Cognitive Impairment in Primary and Secondary Progressive Multiple Sclerosis Cohort-Similar Progressive MS Phenotype.International journal of molecular sciences · 2025Article
- Quantitative brain volumetry in neurological disorders: from disease mechanisms to software solutions.Polish journal of radiology · 2025Review
- Is impairment of facial emotion recognition independent of cognitive dysfunction in multiple sclerosis?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation.Brain communications · 2024Article
- The Probable Infectious Origin of Multiple Sclerosis.NeuroSci · 2023Review
- Gene network revealsFrontiers in neurology · 2023Article
- Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI.Neuroimage. Reports · 2022Article
- Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.Neurorehabilitation and neural repair · 2022Article
- Contrasting the brain imaging features of MOG-antibody disease, with AQP4-antibody NMOSD and multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Article
- Current Methods of Magnetic Resonance for Noninvasive Assessment of Molecular Aspects of Pathoetiology in Multiple Sclerosis.International journal of molecular sciences · 2020Review
- Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis.PloS one · 2020Article
- Optimizing 3D FLAIR to detect MS lesions: pushing past factory settings for precise results.Journal of neurology · 2019Article
- Review
- Improving Detection of Multiple Sclerosis Lesions in the Posterior Fossa Using an Optimized 3D-FLAIR Sequence at 3T.AJNR. American journal of neuroradiology · 2019Article
- Biomedical Variables and Adaptation to Disease and Health-Related Quality of Life in Polish Patients with MS.International journal of environmental research and public health · 2018Article
- How changes in brain activity and connectivity are associated with motor performance in people with MS.NeuroImage. Clinical · 2018Review
- Correlation of MRI findings and cognitive function in multiple sclerosis patients using montreal cognitive assessment test.Medical journal of the Islamic Republic of Iran · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is an immune-mediated disease affecting central nervous system (CNS). Although MS is classically considered a white matter (WM) disease, the involvement of gray matter (GM) in the pathogenic process has been confirmed by pathology studies and MRI studies. Impairment of cognitive domains such as memory, mental processing speed, attention, and executive function can occur from the early stage of the disease and tends to worsen over time, despite stable physical symptoms. WM demyelination is moderately correlated with CI, suggesting that probably WM abnormalities alone cannot fully explain the extent of clinical symptoms in MS, including CI. Several MRI techniques have shown the involvement of GM in MS and the association between GM damage, physical disability, and CI. The aim of this review is to provide an overview of CI and GM damage assessed by structural brain MRI.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.