ReviewTherapeutic advances in neurological disorders2014
Chronic cerebrospinal venous insufficiency and multiple sclerosis: a comprehensive meta-analysis of case-control studies.
Review in Therapeutic advances in neurological disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Differentiation between anatomical slenderness and acquired stenosis of the internal jugular veins.CNS neuroscience & therapeutics · 2022Article
- No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years.BMC neurology · 2019Observational
- Age-related small vessel disease: a potential contributor to neurodegeneration in multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2017Review
- Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis.Current neurovascular research · 2017Article
- Why Current Doppler Ultrasound Methodology Is Inaccurate in Assessing Cerebral Venous Return: The Alternative of the Ultrasonic Jugular Venous Pulse.Behavioural neurology · 2016Review
- Chronic Cerebrospinal Venous Insufficiency: A Failed Concept.Vascular specialist international · 2015Article
- Chronic Cerebrospinal Venous Insufficiency.Vascular specialist international · 2015Article
- Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis: A Failed Concept.Vascular specialist international · 2015Review
- "Liberation treatment" for chronic cerebrospinal venous insufficiency in multiple sclerosis: the truth will set you free.Brain and behavior · 2015Review
- Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association with multiple sclerosis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesChronic cerebrospinal venous insufficiency (CCSVI) has recently been implicated in the pathogenesis of multiple sclerosis (MS). This comprehensive meta-analysis of case-control studies investigates the association of CCSVI with MS.
methodsThrough Medline, EMBASE and Cochrane database searches, case-control ultrasound studies comparing CCSVI frequency among patients with MS and healthy controls were identified.
resultsWe identified 19 eligible studies including 1250 patients with MS and 899 healthy controls. The pooled analysis showed that CCSVI was associated with MS [odds ratio (OR) 8.35; 95% confidence interval (CI) 3.44-20.31; p < 0.001) with considerable heterogeneity across studies (I (2) = 80.1%). This association was substantially attenuated in sensitivity analyses excluding studies that were carried out by the group that originally described CCSVI, included investigators who had also been involved in publications advocating endovascular procedures for CCSVI treatment, or were conducted in Italy. Our most conservative sensitivity analysis combining different exclusion criteria yielded no association of CCSVI with MS (OR 1.35; 95% CI 0.62-2.93; p = 0.453) without any heterogeneity (I (2) = 0%).
conclusionThere is considerable heterogeneity across different case-control studies evaluating the association of CCSVI and MS. The greatest factor contributing to this heterogeneity appears to be the involvement of investigators in other publications supporting endovascular procedures as a novel MS treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.