ArticleTheScientificWorldJournal2014
Blood transfusions in total hip and knee arthroplasty: an analysis of outcomes.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02973074 (Pilot Study for Investigation of the Feasibility and for Optimization of Oral Iron Substitution in the Course of Patient Blood Management for Orthopedic Surgery), which is not on this map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study for Investigation of the Feasibility and for Optimization of Oral Iron Substitution in the Course of Patient Blood Management for Orthopedic Surgery
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effect of Tranexamic Acid on Blood Management during a High Tibial Osteotomy: A Systematic Review and Meta-analysis.Orthopaedic surgery · 2022Pooled it
- Pooled it
- Combined use of intravenous and topical versus intravenous tranexamic acid in primary total knee and hip arthroplasty: a meta-analysis of randomised controlled trials.Journal of orthopaedic surgery and research · 2017Pooled it
- Efficiency and Safety of Intravenous Tranexamic Acid in Simultaneous Bilateral Total Knee Arthroplasty: A Systematic Review and Meta-analysis.Orthopaedic surgery · 2016Pooled it
- The efficacy of a thrombin-based hemostatic agent in primary total knee arthroplasty: a meta-analysis.Journal of orthopaedic surgery and research · 2014Pooled it
- Appropriateness and determinants of packed red blood cell transfusion in knee arthroplasty: a retrospective tertiary hospital study.Scientific reports · 2025Article
- Patient characteristics and adverse effects of allogeneic blood transfusion following lower extremity joint replacement in rheumatoid arthritis: a nationwide inpatient sample database study.BMC rheumatology · 2025Article
- Trends, risk factors, and complications of blood transfusion in primary total knee arthroplasty in China: a nationwide retrospective study.Archives of orthopaedic and trauma surgery · 2025Article
- From research to practice: bridging the implementation gap on the use of tranexamic acid in total knee arthroplasty.Journal of orthopaedic surgery and research · 2025Article
- Comparison of mid-term clinical and radiological results of short and conventional femoral stems in total hip arthroplasty.Scientific reports · 2024Article
- Total Joint Arthroplasty in Patients With an Implanted Left Ventricular Assist Device.Arthroplasty today · 2023Article
- Risk factors analysis and nomogram construction for blood transfusion in elderly patients with femoral neck fractures undergoing hemiarthroplasty.International orthopaedics · 2022Article
- Prognostic Factors of Clinical and Economic Outcomes of Hip Arthroplasty in a Developing Country: A Multilevel Analysis with a 4-Year Cohort Study.Indian journal of orthopaedics · 2022Article
- A novel predictive model of hospital stay for Total Knee Arthroplasty patients.Frontiers in surgery · 2022Article
- Transfusion in orthopaedic surgery : a retrospective multicentre cohort study.Bone & joint open · 2021Article
- Understanding the 30-day mortality burden after revision total knee arthroplasty.Arthroplasty today · 2021Article
- Letter to editor regarding "The efficacy and safety of tranexamic acid in high tibial osteotomy: a systematic review and meta-analysis".Journal of orthopaedic surgery and research · 2021Article
- Preoperative risk factors for postoperative cardiac arrest following primary total hip and knee arthroplasty: A large database study.Journal of clinical orthopaedics and trauma · 2021Article
- The incidence and risk factors for allogenic blood transfusion in total knee and hip arthroplasty.Journal of orthopaedic surgery and research · 2019Observational
- Perioperative allogenic blood transfusion increases the incidence of postoperative deep vein thrombosis in total knee and hip arthroplasty.Journal of orthopaedic surgery and research · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundVarious studies have raised concern of worse outcomes in patients receiving blood transfusions perioperatively compared to those who do not. In this study we attempted to determine the proportion of perioperative complications in the orthopedic population attributable to the use of a blood transfusion.
methodsData from 400 hospitals in the United States were used to identify patients undergoing total hip or knee arthroplasty (THA and TKA) from 2006 to 2010. Patient and health care demographics, as well as comorbidities and perioperative outcomes were compared. Multivariable logistic regression models were fitted to determine associations between transfusion, age, and comorbidities and various perioperative outcomes. Population attributable fraction (PAF) was determined to measure the proportion of outcome attributable to transfusion and other risk factors.
resultsOf 530,089 patients, 18.93% received a blood transfusion during their hospitalization. Patients requiring blood transfusion were significantly older and showed a higher comorbidity burden. In addition, these patients had significantly higher rates of major complications and a longer length of hospitalization. The logistic regression models showed that transfused patients were more likely to have adverse health outcomes than nontransfused patients. However, patients who were older or had preexisting diseases carried a higher risk than use of a transfusion for these outcomes. The need for a blood transfusion explained 9.51% (95% CI 9.12-9.90) of all major complications.
conclusionsAdvanced age and high comorbidity may be responsible for a higher proportion of adverse outcomes in THA and TKA patients than blood transfusions.
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