ArticleTheScientificWorldJournal2014
Prognostic value of C-reactive protein, leukocytes, and vitamin d in severe chronic obstructive pulmonary disease.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- C-reactive protein level predicts mortality in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2017Pooled it
- Predictive score for in-hospital mortality in patients with severe acute exacerbations of chronic obstructive pulmonary disease.Archives of medical science : AMS · 2025Article
- Prognostic Value of Neutrophil to Lymphocyte Ratio for Predicting 90-Day Poor Outcomes in Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Article
- Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study.Respiratory research · 2019Article
- Correlation of severity of chronic obstructive pulmonary disease with serum vitamin-D level.Journal of family medicine and primary care · 2019Article
- Low concentrations of 25-hydroxyvitamin D and long-term prognosis of COPD: a prospective cohort study.European journal of epidemiology · 2018Article
- Serum Cystatin C as an Inflammatory Marker in Exacerbated and Convalescent COPD Patients.Inflammation · 2016Article
- Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease.Inflammation · 2015Article
- Lung function, 25-hydroxyvitamin D concentrations and mortality in US adults.European journal of clinical nutrition · 2015Article
- Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD.International journal of chronic obstructive pulmonary disease · 2015Article
- Neutrophil-to-lymphocyte ratio, calprotectin and YKL-40 in patients with chronic obstructive pulmonary disease: correlations and 5-year mortality - a cohort study.Journal of inflammation (London, England) · 2015Article
- Article
- Soluble urokinase-type plasminogen activator receptor as a measure of treatment response in acute exacerbation of COPD.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory biomarkers predict mortality and hospitalisation in chronic obstructive pulmonary disease (COPD). Yet, it remains uncertain if biomarkers in addition to reflecting disease severity add new prognostic information on severe COPD. We investigated if leukocytes, C-reactive protein (CRP), and vitamin D were independent predictors of mortality and hospitalisation after adjusting for disease severity with an integrative index, the i-BODE index. In total, 423 patients participating in a pulmonary rehabilitation programme, with a mean value of FEV1 of 38% of predicted, were included. Mean followup was 45 months. During the follow-up period, 149 deaths (35%) were observed and 330 patients (78.0%) had at least one acute hospitalisation; 244 patients (57.7%) had at least one hospitalisation due to an exacerbation of COPD. In the analysis (Cox proportional hazards model) fully adjusted for age, sex, and i-BODE index, the hazard ratio for 1 mg/L increase in CRP was 1.02 (P=0.003) and for 1×10(9)/L increase in leukocytes was 1.43 (P=0.03). Only leukocyte count was significantly associated with hospitalisation. Vitamin D was neither associated with mortality nor hospitalisation. Leukocytes and CRP add little information on prognosis and vitamin D does not seem to be a useful biomarker in severe COPD in a clinical setting.
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