ArticleWorld journal of gastroenterology2014
Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: a case report.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Leptomeningeal carcinomatosis in gastric cancer: A Review.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Review
- Leptomeningeal Carcinomatosis in Early Gastric Cancer: A Case Report and Literature Review.Healthcare (Basel, Switzerland) · 2024Article
- Teaching NeuroImage: Cutaneous Lesions and Leptomeningeal Carcinomatosis in Gastric Signet-Ring Cell Carcinoma.Neurology · 2023Article
- Diagnostic and Therapeutic Updates in Leptomeningeal Disease.Current oncology reports · 2023Review
- Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer.Journal of translational medicine · 2023Article
- Autopsy diagnosis of leptomeningeal carcinomatosis, the first manifestation of gastric adenocarcinoma: a rare case report and review of the literature.Gastroenterology and hepatology from bed to bench · 2021Article
- Simultaneous primary cancer occurrence of melanoma and pulmonary adenocarcinoma in leptomeningeal metastases: a case report.BMC cancer · 2019Article
- Meningeal carcinomatosis: three case-reports.World journal of surgical oncology · 2018Article
- Article
- Leptomeningeal Carcinomatosis in Gastric Cancer: A Therapeutical Challenge.Biomarker insights · 2017Article
- Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma: A case report and literature review.Medicine · 2016Review
- Dysphagia and anorexia as presentations of leptomeningeal carcinomatosis.BMJ case reports · 2016Article
- Dural metastasis masquerading as an en plaque meningioma.Journal of neurosciences in rural practiceArticle
- A 56-year-old man with acute vision loss.Digital journal of ophthalmology : DJOArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptomeningeal involvement is usually reported as a secondary event in advanced gastric carcinoma. Leptomeningeal carcinomatosis (LMC), as the initial manifestation of asymptomatic gastric cancer, is exceedingly rare with only a few cases reported in recent years. The presenting neurologic symptoms include headache, vomiting and seizures and are usually clinically atypical. The diagnosis of LMC is made via identification of malignant cells that originate from epithelial cells in the cerebrospinal fluid by cytological examination and provides cues to track the primary tumor. Endoscopic examinations are crucial to confirm the presence of gastric cancer, and imaging studies, especially gadolinium-enhanced magnetic resonance imaging of the brain, are sometimes helpful in diagnosis. Thus far, there is no standard therapy for LMC, and despite all measures, the prognosis of the condition is extremely poor. Here, we report on the clinical features and diagnostic procedures for a patient with occult gastric cancer with Bormann type I macroscopic appearance and poor differentiation in pathology, who presented with LMC-induced neurological symptoms as the initial clinical manifestation. Additionally, we review the similar cases reported over the past years, making comparison among cases in order to provide more information for the future diagnosis.
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