ArticleSleep2014
Cytokine polymorphisms are associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Genetic regulation of lncRNA expression in whole human brain and their contribution to CNS disorders.Briefings in bioinformatics · 2025Article
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- Sleep Disorders in Human Immunodeficiency Virus: A Substudy of the Pharmacokinetics and Clinical Observations in People Over Fifty (POPPY) Study.Open forum infectious diseases · 2021Article
- Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study.PloS one · 2021Article
- The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa.Frontiers in immunology · 2021Review
- Sleep patterns and problems among children with 22q11 deletion syndrome.Molecular genetics & genomic medicine · 2020Article
- Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Differential relationships between cannabis consumption and sleep health as a function of HIV status.Drug and alcohol dependence · 2018Article
- Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer.Journal of pain and symptom management · 2018Article
- Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy.Journal of pain and symptom management · 2017Article
- Cytokine polymorphisms are associated with daytime napping in adults living with HIV.Sleep medicine · 2017Article
- Article
- Engagement in Care, Psychological Distress, and Resilience are Associated with Sleep Quality among HIV-Positive Gay, Bisexual, and Other Men Who Have Sex with Men.Sleep health · 2016Article
- An insight of sleep disorders in Africa.eNeurologicalSci · 2016Review
- Article
- Cytokine polymorphisms and plasma levels are associated with sleep onset insomnia in adults living with HIV/AIDS.Brain, behavior, and immunity · 2015Article
- The ongoing need for good physiological investigation: obstructive sleep apnea in HIV patients as a paradigm.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Sleep, Fatigue, and Problems With Cognitive Function in Adults Living With HIV.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesCytokine activity and polymorphisms have been associated with sleep outcomes in prior animal and human research. The purpose of this study was to determine whether circulating plasma cytokines and cytokine polymorphisms are associated with the poor sleep maintenance commonly experienced by adults living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS).
designCross-sectional descriptive study.
settingHIV clinics and community sites in the San Francisco Bay area.
participantsA convenience sample of 289 adults (193 men, 73 women, and 23 transgender) living with HIV/AIDS.
interventionsNone. MEASUREMENTS AND
resultsA wrist actigraph was worn for 72 h to estimate the percentage of wake after sleep onset (WASO%) and total sleep time (TST), plasma cytokines were analyzed, and genotyping was conducted for 15 candidate genes involved in cytokine signaling: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL1B, IL1R2, IL1R2, IL2, IL4, IL6, IL8, IL10, IL13, IL17A), nuclear factor of kappa light polypeptide gene enhancer in B cells (NFKB1 and NFKB2), and tumor necrosis factor-alpha (TNFA). Controlling for demographic variables such as race and sex, and clinical variables such as CD4+ count and medications, higher WASO% was associated with single nucleotide polymorphisms (SNPs) of IL1R2 rs11674595 and TNFA rs1041981 and less WASO% was associated with IL2 rs2069776. IL1R2 rs11674595 and TNFA rs1041981 were also associated with short sleep duration.
conclusionsThis study strengthens the evidence for an association between inflammation and sleep maintenance problems. In this chronic illness population, cytokine polymorphisms associated with wake after sleep onset provide direction for intervention research aimed at comparing anti-inflammatory mechanisms with hypnotic agents for improving sleep maintenance and total sleep time.
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Registered trials
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