ArticleSleep2014
Associations between subjective sleep quality and brain volume in Gulf War veterans.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- Brain signature of sleep quality.Sleep · 2025Article
- Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder.Military Medical Research · 2024Article
- Cortical lobar volume reductions associated with homocysteine-related subcortical brain atrophy and poorer cognition in healthy aging.Frontiers in aging neuroscience · 2024Article
- Investigating a clinically informed sleep disturbance threshold for physical and mental health among Gulf War Illness veterans.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Associations between sleep health and grey matter volume in the UK Biobank cohort (Brain communications · 2023Article
- Correlations between sleep disturbance and brain structures associated with neurodegeneration in the National Alzheimer's Coordinating Center Uniform Data Set.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022Article
- Poor sleep accelerates hippocampal and posterior cingulate volume loss in cognitively normal healthy older adults.Journal of sleep research · 2022Article
- Association of white matter volume with sleep quality: a voxel-based morphometry study.Brain imaging and behavior · 2022Article
- Ventromedial and insular cortical volume moderates the relationship between BDNF Val66Met and threat sensitivity.Journal of psychiatric research · 2021Article
- Gulf War veterans exhibit broadband sleep EEG power reductions in regions overlying the frontal lobe.Life sciences · 2021Article
- Specific cortical and subcortical grey matter regions are associated with insomnia severity.PloS one · 2021Article
- Relationship between internet addiction and sleep disturbance in high school students: a cross-sectional study.BMC pediatrics · 2020Article
- Instability of brain connectivity during nonrapid eye movement sleep reflects altered properties of information integration.Human brain mapping · 2019Article
- Systematic genetic analyses of GWAS data reveal an association between the immune system and insomnia.Molecular genetics & genomic medicine · 2019Article
- Child abuse interacts with hippocampal and corpus callosum volume on psychophysiological response to startling auditory stimuli in a sample of veterans.Journal of psychiatric research · 2019Article
- Article
- Association among anterior cingulate cortex volume, psychophysiological response, and PTSD diagnosis in a Veteran sample.Neurobiology of learning and memory · 2018Article
- Time-dependent differences in cortical measures and their associations with behavioral measures following mild traumatic brain injury.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTo investigate whether subjective sleep quality is associated with brain volume independent of comorbid psychiatric conditions.
designCross-sectional.
settingDepartment of Veterans Affairs (VA) Medical Center.
participantsOne hundred forty-four Gulf War Veterans (mean age 45 years; range: 31-70 years; 14% female).
interventionsNone. MEASUREMENTS AND
resultsTotal cortical, lobar gray matter, and hippocampal volumes were quantified from 1.5 Tesla magnetic resonance images using Freesurfer version 4.5. Subjective sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regressions were used to determine the association of sleep quality with total and regional brain volumes. The global PSQI score was positively correlated with lifetime and current posttraumatic stress disorder (PTSD) and current depressive symptoms (P < 0.001) and was higher in veterans with Gulf War Illness, trauma exposure, and those using psychotropic medication (P ≤ 0.03). After adjusting for these comorbid variables, age, intracranial volume, and multiple comparisons, global PSQI was inversely associated with total cortical and frontal gray matter volume (adjusted P ≤ 0.03). Within the frontal lobe, total PSQI was inversely associated with the superior and middle frontal, orbitofrontal, anterior cingulate, and frontal pole volumes (adjusted P ≤ 0.02). Examination of the 3-factor structure of the PSQI revealed that the associations were driven by perceived sleep quality.
conclusionsPoorer subjective sleep quality was associated with reduced total cortical and regional frontal lobe volumes independent of comorbid psychiatric conditions. Future work will be needed to examine if effective treatment of disturbed sleep leads to improved structural and functional integrity of the frontal lobes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.