ArticlePloS one2014
The concentration of iron in real-world geogenic PM₁₀ is associated with increased inflammation and deficits in lung function in mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells.Respiratory research · 2025Article
- Preventive Effects of Vanillic Acid Against Lung Inflammation and Oxidative Stress Induced by Dust Particles in Wistar Rats.Journal of cellular and molecular medicine · 2025Article
- Physicochemical Properties and Bioreactivity of Sub-10 μm Geogenic Particles: Comparison of Volcanic Ash and Desert Dust.GeoHealth · 2025Article
- Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems.Environmental health perspectives · 2025Article
- Effects of chemical composition on the lung cell response to coal particles: Implications for coal workers' pneumoconiosis.Respirology (Carlton, Vic.) · 2022Article
- Seasonal and monthly variation in peak expiratory flow rate in children with asthma.Asia Pacific allergy · 2021Article
- SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?Annals of the New York Academy of Sciences · 2021Review
- Effects of Particulate Matter 10 Inhalation on Lung Tissue RNA expression in a Murine Model.Tuberculosis and respiratory diseases · 2021Article
- Iron Oxide Particles Alter Bacterial Uptake and the LPS-Induced Inflammatory Response in Macrophages.International journal of environmental research and public health · 2020Article
- Inorganic particulate matter modulates non-typeable Haemophilus influenzae growth: a link between chronic bacterial infection and geogenic particles.Environmental geochemistry and health · 2020Article
- Association between ambient air pollution and out-of-hospital cardiac arrest: are there potentially susceptible groups?Journal of exposure science & environmental epidemiology · 2020Article
- The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children.International journal of environmental research and public health · 2019Article
- Article
- Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies - Mechanism and effects of particle size and iron.Chemico-biological interactions · 2017Article
- The Effect of Seasonal Variations in Airborne Particulate Matter on Asthma-Related Airway Inflammation in Mice.International journal of environmental research and public health · 2016Article
- Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8.International journal of environmental research and public health · 2015Article
- Difference in Pro-Inflammatory Cytokine Responses Induced in THP1 Cells by Particulate Matter Collected on Days with and without ASIAN Dust Storms.International journal of environmental research and public health · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are many communities around the world that are exposed to high levels of particulate matter <10 µm (PM₁₀) of geogenic (earth derived) origin. Mineral dusts in the occupational setting are associated with poor lung health, however very little is known about the impact of heterogeneous community derived particles. We have preliminary evidence to suggest that the concentration of iron (Fe) may be associated with the lung inflammatory response to geogenic PM₁₀. We aimed to determine which physico-chemical characteristics of community sampled geogenic PM₁₀ are associated with adverse lung responses.
methodsWe collected geogenic PM₁₀ from four towns in the arid regions of Western Australia. Adult female BALB/c mice were exposed to 100 µg of particles and assessed for inflammatory and lung function responses 6 hours, 24 hours and 7 days post-exposure. We assessed the physico-chemical characteristics of the particles and correlated these with lung outcomes in the mice using principal components analysis and multivariate linear regression.
resultsGeogenic particles induced an acute inflammatory response that peaked 6 hours post-exposure and a deficit in lung mechanics 7 days post-exposure. This deficit in lung mechanics was positively associated with the concentration of Fe and particle size variability and inversely associated with the concentration of Si.
conclusionsThe lung response to geogenic PM₁₀ is complex and highly dependent on the physico-chemical characteristics of the particles. In particular, the concentration of Fe in the particles may be a key indicator of the potential population health consequences for inhaling geogenic PM₁₀.
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