ArticlePloS one2014
PRB1 is required for clipping of the histone H3 N terminal tail in Saccharomyces cerevisiae.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Specific tracking of N-terminal clipping on histone H3 inMarine life science & technology · 2026Article
- Retromer Regulates Macro- and Micro-Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Histone Tail Cleavage as a Mechanism for Epigenetic Regulation.International journal of molecular sciences · 2024Review
- Genetic profiling of azoospermic men to identify the etiology and predict reproductive potential.Journal of assisted reproduction and genetics · 2024Article
- A Rapid and Efficient Method for the Extraction of Histone Proteins.Journal of proteome research · 2023Article
- Article
- The micronuclear histone H3 clipping in the unicellular eukaryoteMarine life science & technology · 2022Review
- Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation.Nature immunology · 2021Article
- Proteomic Analysis ofMolecules (Basel, Switzerland) · 2020Article
- The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae.Microbial cell factories · 2018Review
- A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell's mass degradation processes.Microbial cell (Graz, Austria) · 2018Review
- Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression.BMB reports · 2018Review
- Proteolysis suppresses spontaneous prion generation in yeast.The Journal of biological chemistry · 2017Article
- JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress.EMBO reports · 2017Article
- Functions for diverse metabolic activities in heterochromatin.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis.Genes & development · 2016Article
- Low Proteolytic Clipping of Histone H3 in Cervical Cancer.Journal of Cancer · 2016Article
- Histone proteolysis: a proposal for categorization into 'clipping' and 'degradation'.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.PloS one · 2015Article
- Enzymatic cleavage of histone H3: a new consideration when measuring histone modifications in human samples.Clinical epigenetics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cathepsin L, a lysosomal protein in mouse embryonic stem cells has been shown to clip the histone H3 N- terminus, an activity associated with gene activity during mouse cell development. Glutamate dehydrogenase (GDH) was also identified as histone H3 specific protease in chicken liver, which has been connected to gene expression during aging. In baker's yeast, Saccharomyces cerevisiae, clipping the histone H3 N-terminus has been associated with gene activation in stationary phase but the protease responsible for the yeast histone H3 endopeptidase activity had not been identified. In searching for a yeast histone H3 endopeptidase, we found that yeast vacuolar protein Prb1 is present in the cellular fraction enriched for the H3 N-terminus endopeptidase activity and this endopeptidase activity is lost in the PRB1 deletion mutant (prb1Δ). In addition, like Cathepsin L and GDH, purified Prb1 from yeast cleaves H3 between Lys23 and Ala24 in the N-terminus in vitro as shown by Edman degradation. In conclusion, our data argue that PRB1 is required for clipping of the histone H3 N-terminal tail in Saccharomyces cerevisiae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.