ArticlePloS one2014
Gene expression changes for antioxidants pathways in the mouse cochlea: relations to age-related hearing deficits.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Age-related hearing loss involves mitochondrial DNA instability and copy number depletion in the cochlea: Insights from in vivo and in vitro models.Hearing research · 2026Article
- Decoding thymic development: a single-cell atlas of tree shrew immunity.Frontiers in immunology · 2025Article
- Revisiting Fold-Change Calculation: Preference for Median or Geometric Mean over Arithmetic Mean-Based Methods.Biomedicines · 2024Article
- Connexins 30 and 43 expression changes in relation to age-related hearing loss.Hearing research · 2024Article
- Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic.Life (Basel, Switzerland) · 2023Review
- Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection.Journal of virus eradication · 2023Review
- Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy.Cancer medicine · 2022Article
- Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth.Cellular and molecular life sciences : CMLS · 2022Article
- Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas.Frontiers in cell and developmental biology · 2022Article
- Prognostic Gene Expression Signature for Age-Related Hearing Loss.Frontiers in medicine · 2022Article
- SOD2 Alleviates Hearing Loss Induced by Noise and Kanamycin in Mitochondrial DNA4834-deficient Rats by Regulating PI3K/MAPK Signaling.Current medical science · 2021Article
- The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021Article
- Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors' Transcription During Oocyte Growth.Frontiers in cell and developmental biology · 2021Article
- Analysis of Factors Affecting Cranial Nerve Function of Patients With Vascular Mild Cognitive Impairment Through Functional Magnetic Resonance Imaging Under Artificial Intelligence Environment.Frontiers in public health · 2021Article
- Pathology and mechanisms of cochlear aging.Journal of neuroscience research · 2020Review
- A novel familial 9q31.2q32 microdeletion: Muscle cramping, somnolence, fatigue, sensorineural hearing loss, pubertal delay, and short stature.Clinical case reports · 2019Article
- Decreased levels of superoxide dismutase in inner pillar cells contribute to ribbon synapse impairment in presbycusis.American journal of translational research · 2019Article
- Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.The Journal of clinical investigation · 2018Article
- Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice.Scientific reports · 2018Article
- Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.Neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Age-related hearing loss - presbycusis - is the number one neurodegenerative disorder and top communication deficit of our aged population. Like many aging disorders of the nervous system, damage from free radicals linked to production of reactive oxygen and/or nitrogen species (ROS and RNS, respectively) may play key roles in disease progression. The efficacy of the antioxidant systems, e.g., glutathione and thioredoxin, is an important factor in pathophysiology of the aging nervous system. In this investigation, relations between the expression of antioxidant-related genes in the auditory portion of the inner ear - cochlea, and age-related hearing loss was explored for CBA/CaJ mice. Forty mice were classified into four groups according to age and degree of hearing loss. Cochlear mRNA samples were collected and cDNA generated. Using Affymetrix® GeneChip, the expressions of 56 antioxidant-related gene probes were analyzed to estimate the differences in gene expression between the four subject groups. The expression of Glutathione peroxidase 6, Gpx6; Thioredoxin reductase 1, Txnrd1; Isocitrate dehydrogenase 1, Idh1; and Heat shock protein 1, Hspb1; were significantly different, or showed large fold-change differences between subject groups. The Gpx6, Txnrd1 and Hspb1 gene expression changes were validated using qPCR. The Gpx6 gene was upregulated while the Txnrd1 gene was downregulated with age/hearing loss. The Hspb1 gene was found to be downregulated in middle-aged animals as well as those with mild presbycusis, whereas it was upregulated in those with severe presbycusis. These results facilitate development of future interventions to predict, prevent or slow down the progression of presbycusis.
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Registered trials
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