ArticlePloS one2014
T helper cell subsets specific for Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Immune system dynamics in response to Pseudomonas aeruginosa biofilms.NPJ biofilms and microbiomes · 2025Review
- Chronic suppurative otitis media: disrupted host-microbial interactions and immune dysregulation.Frontiers in immunology · 2025Review
- Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients.Frontiers in immunology · 2024Article
- Article
- Immune Response to Biofilm Growing PulmonaryBiomedicines · 2022Review
- Article
- RecombinantInfection and immunity · 2021Article
- AVaccines · 2021Article
- Immune Responses toFrontiers in immunology · 2021Review
- T Cells in Fibrosis and Fibrotic Diseases.Frontiers in immunology · 2020Review
- Liposomes Loaded With Phosphatidylinositol 5-Phosphate Improve the Antimicrobial Response toFrontiers in immunology · 2020Article
- Review
- Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection.American journal of respiratory and critical care medicine · 2018Review
- The diversity of myeloid immune cells shaping wound repair and fibrosis in the lung.Regeneration (Oxford, England) · 2018Review
- Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17‑mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro.Molecular medicine reports · 2017Article
- Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models.Scientific reports · 2017Article
- Interleukin-17 Is Required for Control of Chronic Lung Infection Caused by Pseudomonas aeruginosa.Infection and immunity · 2016Article
- IL-22 exacerbates weight loss in a murine model of chronic pulmonary Pseudomonas aeruginosa infection.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2016Article
- Poly-functional and long-lasting anticancer immune response elicited by a safe attenuatedMolecular therapy oncolytics · 2016Article
- CD26 Expression on T Helper Populations and sCD26 Serum Levels in Patients with Rheumatoid Arthritis.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe set out to determine the magnitude of antigen-specific memory T helper cell responses to Pseudomonas aeruginosa in healthy humans and patients with cystic fibrosis.
methodsPeripheral blood human memory CD4(+) T cells were co-cultured with dendritic cells that had been infected with different strains of Pseudomonas aeruginosa. The T helper response was determined by measuring proliferation, immunoassay of cytokine output, and immunostaining of intracellular cytokines.
resultsHealthy individuals and patients with cystic fibrosis had robust antigen-specific memory CD4(+) T cell responses to Pseudomonas aeruginosa that not only contained a Th1 and Th17 component but also Th22 cells. In contrast to previous descriptions of human Th22 cells, these Pseudomonal-specific Th22 cells lacked the skin homing markers CCR4 or CCR10, although were CCR6(+). Healthy individuals and patients with cystic fibrosis had similar levels of Th22 cells, but the patient group had significantly fewer Th17 cells in peripheral blood.
conclusionsTh22 cells specific to Pseudomonas aeruginosa are induced in both healthy individuals and patients with cystic fibrosis. Along with Th17 cells, they may play an important role in the pulmonary response to this microbe in patients with cystic fibrosis and other conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.