ArticlePloS one2014
Independent expansion of zincin metalloproteinases in Onygenales fungi may be associated with their pathogenicity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Infectivity of amphibian chytrid fungi requires metalloprotease-driven spore development and germ tube formation.BMC microbiology · 2026Article
- Evolutionary History and Diversification of M35 Metalloproteases in Dothideomycetes: A Phylogenomic Overview and Case Study in Corynespora cassiicola.Current microbiology · 2026Article
- Universal signatures of transposable element compartmentalization across eukaryotic genomes.bioRxiv : the preprint server for biology · 2024Article
- Expression Profiles of Protease in Onychomycosis-Related Pathogenic Trichophyton rubrum and Tinea Capitis-Related Pathogenic Trichophyton violaceum.Mycopathologia · 2024Article
- Two-speed genome evolution drives pathogenicity in fungal pathogens of animals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Two Metalloproteases VdM35-1 and VdASPF2 from Verticillium dahliae Are Required for Fungal Pathogenicity, Stress Adaptation, and Activating Immune Response of Host.Microbiology spectrum · 2022Article
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- Defeated by the nines: nine extracellular strategies to avoid microbe-associated molecular patterns recognition in plants.The Plant cell · 2021Article
- A Review ofCurrent clinical microbiology reports · 2021Review
- Microbial enzymes catalyzing keratin degradation: Classification, structure, function.Biotechnology advances · 2020Review
- Genome-Wide Identification of M35 Family Metalloproteases inInternational journal of molecular sciences · 2020Article
- Evolution and comparative genomics of the most common Trichoderma species.BMC genomics · 2019Article
- Cryptococcal Traits Mediating Adherence to Biotic and Abiotic Surfaces.Journal of fungi (Basel, Switzerland) · 2018Review
- Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli.Emerging microbes & infections · 2018Article
- Phylogeny of dermatophytes with genomic character evaluation of clinically distinctStudies in mycology · 2018Article
- Fungal Genomes and Insights into the Evolution of the Kingdom.Microbiology spectrum · 2017Article
- The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity.Scientific reports · 2017Article
- Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.Scientific reports · 2017Article
- The Metalloprotease, Mpr1, Engages AnnexinA2 to Promote the Transcytosis of Fungal Cells across the Blood-Brain Barrier.Frontiers in cellular and infection microbiology · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To get a comprehensive view of fungal M35 family (deuterolysin) and M36 family (fungalysin) genes, we conducted genome-wide investigations and phylogenetic analyses of genes in these two families from 50 sequenced Ascomycota fungi with different life styles. Large variations in the number of M35 family and M36 family genes were found among different fungal genomes, indicating that these two gene families have been highly dynamic through fungal evolution. Moreover, we found obvious expansions of Meps in two families of Onygenales: Onygenaceae and Arthodermataceae, whereas species in family Ajellomycetace did not show expansion of these genes. The strikingly different gene duplication and loss patterns in Onygenales may be associated with the different pathogenicity of these species. Interestingly, likelihood ratio tests (LRT) of both M35 family and M36 family genes suggested that several branches leading to the duplicated genes in dermatophytic and Coccidioides fungi had signatures of positive selection, indicating that the duplicated Mep genes have likely diverged functionally to play important roles during the evolution of pathogenicity of dermatophytic and Coccidioides fungi. The potentially positively selected residues discovered by our analysis may have contributed to the development of new physiological functions of the duplicated Mep genes in dermatophytic fungi and Coccidioides species. Our study adds to the current knowledge of the evolution of Meps in fungi and also establishes a theoretical foundation for future experimental investigations.
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