ArticlePloS one2014
The complex genetic context of blaPER-1 flanked by miniature inverted-repeat transposable elements in Acinetobacter johnsonii.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- TnMicrobial genomics · 2026Article
- Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinicalFrontiers in microbiology · 2025Article
- Unveiling host-parasite relationships through conserved MITEs in prokaryote and viral genomes.Nucleic acids research · 2024Article
- Pan-Genome Plasticity and Virulence Factors: A Natural Treasure Trove forAntibiotics (Basel, Switzerland) · 2024Review
- Review
- Global Epidemiology and Mechanisms of Resistance of Acinetobacter baumannii-calcoaceticus Complex.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.Annals of the New York Academy of Sciences · 2022Review
- A clinicalFrontiers in microbiology · 2022Article
- Ubiquitous Conjugative Mega-Plasmids ofFrontiers in microbiology · 2021Article
- The carbapenem resistance gene blaAntimicrobial resistance and infection control · 2020Article
- MITEmSphere · 2019Article
- Mobile Genetic Elements Associated with Antimicrobial Resistance.Clinical microbiology reviews · 2018Review
- GES-14-Producing Acinetobacter baumannii Isolates in a Neonatal Intensive Care Unit in Tunisia Are Associated with a Typical Middle East Clone and a Transferable Plasmid.Antimicrobial agents and chemotherapy · 2017Article
- Molecular Epidemiology and Genetic Characteristics of Various blaPER Genes in Shanghai, China.Antimicrobial agents and chemotherapy · 2016Article
- The Genetic Analysis of an Acinetobacter johnsonii Clinical Strain Evidenced the Presence of Horizontal Genetic Transfer.PloS one · 2016Article
- Genome-sequence analysis of Acinetobacter johnsonii MB44 reveals potential nematode-virulent factors.SpringerPlus · 2016Article
- Molecular characterization of ISCR1-mediated blaPER-1 in a non-O1, non-O139 Vibrio cholerae strain from China.Antimicrobial agents and chemotherapy · 2015Article
- Resources for Genetic and Genomic Analysis of Emerging Pathogen Acinetobacter baumannii.Journal of bacteriology · 2015Article
- Production of plasmid-encoding NDM-1 in clinical Raoultella ornithinolytica and Leclercia adecarboxylata from China.Frontiers in microbiology · 2015Article
- Complete nucleotide sequence of a conjugative plasmid carrying bla(PER-1).Antimicrobial agents and chemotherapy · 2015Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
On a large plasmid of Acinetobacter johnsonii strain XBB1 from hospital sewage, blaPER-1 and ISCR1 were found in a complex Tn402-like integron carrying an arr3-aacA4 cassette array. The integron was truncated by the same 439-bp miniature inverted-repeat transposable element (MITE) at both ends. blaPER-1 and its complex surroundings might have been mobilized by the MITEst into an orf of unknown function, evidenced by the presence of the characteristic 5-bp direct target repeats. The same 439-bp MITEs have also been found flanking class 1 integrons carrying metallo-β-lactamases genes bla IMP-1, bla IMP-5 and bla VIM-2 before but without ISCR1. Although the cassette arrays are different, integrons have always been truncated by the 439-bp MITEs at the exact same locations. The results suggested that MITEs might be able to mobilize class 1 integrons via transposition or homologous recombination and therefore represent a possible common mechanism for mobilizing antimicrobial resistance determinants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.