SynthesisPloS one2014
Body mass index and risk of age-related cataract: a meta-analysis of prospective cohort studies.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Body mass index influences age-related cataracts: an updated meta-analysis and systemic review.Arquivos brasileiros de oftalmologia · 2024Pooled it
- Association between obesity and age-related cataract: an updated systematic review and dose-response meta-analysis of prospective cohort studies.Frontiers in nutrition · 2023Pooled it
- Obesity and risk of age-related eye diseases: a systematic review of prospective population-based studies.International journal of obesity (2005) · 2021Pooled it
- Body mass index and risk of diabetic retinopathy: A meta-analysis and systematic review.Medicine · 2017Pooled it
- XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis.Molecular vision · 2015Pooled it
- Influence of Cardiometabolic Disease on Macular Structural Changes After Uncomplicated Phacoemulsification.Journal of clinical medicine · 2026Article
- Causal association between cataract and psychiatric disorders: A bidirectional 2-sample Mendelian randomization study.Medicine · 2026Article
- Crucial involvement of transforming growth factor beta (TGF-β)/Smad signaling regulation by miR-204-5p in cataract and posterior capsular opacification.Biochemistry and biophysics reports · 2026Review
- Global burden for blindness and vision loss among women of childbearing age and perimenopause: age-period-cohort analysis 2021.Scientific reports · 2026Article
- Causal effect of obesity on cataract and mediating roles of metabolites: a Mendelian randomization study.International journal of ophthalmology · 2026Article
- Prevalence and risk factors of pre-senile lens opacities in the 1969-73 Vellore Birth Cohort.Eye (London, England) · 2025Article
- The potential role of adipokines and hepatokines in age-related ocular diseases.Metabolism open · 2025Review
- Risk Factors for Cataracts in Patients with Diabetes Mellitus.Journal of clinical medicine · 2024Article
- Association of body mass index andHeliyon · 2023Article
- Prevalence and risk factors for cataracts in the Lao People's Democratic Republic: The Vientiane Eye Study.Indian journal of ophthalmology · 2022Article
- Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study.Scientific reports · 2022Article
- Body mass index is not associated with early onset cataract in the 45 and Up cohort study.Annals of translational medicine · 2021Article
- Relationship between Cataract Surgery and Mortality in Elderly Patients with Cataract: Nationwide Population-Based Cohort Study in South Korea.Journal of personalized medicine · 2021Article
- Healthy Aging-Nutrition Matters: Start Early and Screen Often.Advances in nutrition (Bethesda, Md.) · 2021Review
- Investigation of MicroRNA Expression in Anterior Lens Capsules of Senile Cataract Patients and MicroRNA Differences According to the Cataract Type.Translational vision science & technology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-related cataract (ARC) is the leading cause of blindness in the world. The relationship between body mass index (BMI) and risk of ARC is controversial across observational studies. We therefore performed this meta-analysis to evaluate the association between BMI and risk of ARC.
methodsEligible studies were identified through an electronic search of PubMed, Embase and the Cochrane Library. We pooled study-specific relative risks (RRs) and 95% confidence intervals (CIs) to determine the risk of ARC associated with BMI categories and per 1 kg/m² increase in BMI.
resultsA total of 17 prospective cohort studies were included in the meta-analysis. The pooled RRs of ARC were 1.08 (95% CI, 1.01-1.16) for overweight and 1.19 (95% CI, 1.10-1.28) for obesity compared with normal weight. These findings were robust when stratified by sex, sample source, outcome types and confounders, while significantly differed by assessment of BMI and ARC, and duration of follow-up. The summary RR suggested that per 1 kg/m² increase in BMI was associated with a 2% increased risk of ARC (RR 1.02, 95% CI 1.01-1.03). Pooled estimates of RRs consistently indicated a trend for subjects with a high BMI to develop posterior subcapsular cataracts (RR 1.19, 95% CI 1.06-1.35, for overweight; RR 1.50, 95% CI 1.24-1.81, for obesity; RR 1.04, 95% CI 1.01-1.06, per 1 kg/m² increase in BMI) other than nuclear or cortical cataracts.
conclusionsThe overall findings suggest that elevated BMI may increase the risk of ARC, especially posterior subcapsular cataracts. Further trials are needed to investigate the effect of weight reduction in obese populations on the risk of ARC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.