ArticlePloS one2014
Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- The Multifaceted Menace ofBiology · 2026Review
- Prevalence and diversity of antifungal resistance inAntimicrobial agents and chemotherapy · 2025Article
- Host-specific adaptation inmBio · 2025Article
- Transposons and accessory genes drive adaptation in a clonally evolving fungal pathogen.Nature communications · 2025Article
- In vivo and in vitro pathogenicity of Fusarium oxysporum and its biofilm components.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Virulence ofbioRxiv : the preprint server for biology · 2025Article
- The Dual PathogenJournal of fungi (Basel, Switzerland) · 2025Review
- Bacterial hitchhikers derive benefits from fungal housing.Current biology : CB · 2022Article
- Janus-Faced Molecules against Plant Pathogenic Fungi.International journal of molecular sciences · 2021Review
- Article
- The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes.Communications biology · 2020Article
- Article
- MultiresistantInfection and drug resistance · 2019Review
- Methodologies forMicrobial cell (Graz, Austria) · 2018Review
- Live-cell imaging of conidial anastomosis tube fusion during colony initiation in Fusarium oxysporum.PloS one · 2018Article
- Fungal model systems and the elucidation of pathogenicity determinants.Fungal genetics and biology : FG & B · 2014Review
- Hyphal growth of phagocytosed Fusarium oxysporum causes cell lysis and death of murine macrophages.PloS one · 2014Article
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show that the symptoms of disseminated fusariosis caused by F. oxysporum in immunosuppressed mice are remarkably similar to those reported in humans. Distinct fungal structures were observed inside the host, depending on the infected organ. Invasive hyphae developed in the heart and kidney, causing massive colonization of the organs. By contrast, chlamydospore-like survival structures were found in lung, spleen and liver. Systemically infected mice also developed skin and eye infections, as well as thrombosis and necrosis in the tail. We further show that F. oxysporum can disseminate and persist in the organs of immunocompetent animals, and that these latent infections can lead to lethal systemic fusariosis if the host is later subjected to immunosuppressive treatment.
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