ArticlePloS one2014
Molecular epidemiology and antimicrobial susceptibility of clinical Staphylococcus aureus from healthcare institutions in Ghana.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tracking of multidrug-resistant pathogen clones in Ghana: a systematic review and meta-analysis.BMC medical genomics · 2025Pooled it
- Knowledge, Attitude, and Practices of Nurses on Antimicrobial Resistance.Health science reports · 2026Article
- Molecular typing of PVL-positive Staphylococcus aureus isolates from Lithuania and genome sequencing of a local outbreak strain.Scientific reports · 2026Article
- The combination of mupirocin and Kayvirus broadens the decolonization effect against Staphylococcus aureus.Applied microbiology and biotechnology · 2026Article
- Codon bias variation in Staphylococcus aureus.PloS one · 2026Article
- Prevalence and associated risk factors of Staphylococcus aureus nasal colonization among a cohort of immunocompromised individuals in Lagos, Nigeria.BMC infectious diseases · 2025Article
- Multidrug resistance including borderline-oxacillin resistance and spa typing of Staphylococcus aureus from milk and milk products of Tigray region, Northern Ethiopia.BMC veterinary research · 2025Article
- Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles ofMicroorganisms · 2025Article
- Rapid Detection of Panton-Valentine Leukocidin Production in Clinical Isolates ofPathogens (Basel, Switzerland) · 2025Article
- Article
- Methicillin-resistantVeterinary world · 2024Review
- Displacement of Hospital-Acquired, Methicillin-ResistantMicroorganisms · 2024Article
- Clonal Complexes Distribution ofAntibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial resistance and clonality ofFrontiers in microbiology · 2023Article
- Characterisation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Characteristics ofPathogens (Basel, Switzerland) · 2022Article
- Local Epidemiology of NosocomialAntibiotics (Basel, Switzerland) · 2022Article
- Prevalence and genetic lineages ofIJID regions · 2022Review
- Survey of Staphylococcus aureus carriage by free-living red deer (Cervus elaphus): Evidence of human and domestic animal lineages.Transboundary and emerging diseases · 2022Article
- Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to determine the antimicrobial susceptibility patterns and clonal diversity of clinical Staphylococcus aureus isolates from Ghana. A total of 308 S. aureus isolates from six healthcare institutions located across Northern, Central and Southern Ghana were characterized by antibiotyping, spa typing and PCR detection of Panton Valentine leukocin (PVL) genes. Methicillin-resistant S. aureus (MRSA) were confirmed by PCR detection of mecA gene and further characterized by SCCmec and multi-locus sequence typing (MLST). The prevalence of antimicrobial resistance was below 5% for all agents tested except for penicillin (97%), tetracycline (42%) and erythromycin (6%). Ninety-one spa types were found, with t355 (ST152, 19%), t084 (ST15, 12%) and t314 (ST121, 6%) being the most frequent types. Based on established associations between spa and MLST types, isolates were assigned to 16 clonal complexes (CCs): CC152 (n = 78), CC15 (n = 57), CC121 (n = 39), CC8 (n = 36), CC5 (n = 33), CC1 (n = 29), CC45 (n = 9), CC88 (n = 8), CC30 (n = 4), CC9 (n = 3), CC25 (n = 2), CC97 (n = 2) CC20 (n = 2), CC707 (n = 2), CC7 (n = 3) and CC522 (n = 1). Most isolates (60%) were PVL-positive, especially those belonging to ST152, ST121, ST5, ST15, ST1, ST8, and ST88. Nine (3%) isolates were MRSA belonging to seven distinct clones: ST88-IV (n = 2), ST250-I (n = 2), ST8-IV (n = 1), ST72-V (n = 1), ST789-IV (n = 1), ST2021-V (n = 1), and ST239-III (n = 1). The study confirmed a high frequency of PVL-positive S. aureus in Africa, low prevalence of antimicrobial resistance and high diversity of MRSA lineages in Ghana compared to developed countries and other African countries. The detection of known pandemic MRSA clones in the absence of routine MRSA identification in most Ghanaian clinical microbiology laboratories calls for capacity building to strengthen surveillance and prevent spread of these clones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.