Evidence map›Paper›PMID 24586979›Full record

ArticlePloS one2014

Growth development of French children born after in vitro maturation.

Laurence Foix-L'Hélias, Michael Grynberg, Béatrice Ducot, Nelly Frydman, Violaine Kerbrat, Jean Bouyer, Philippe Labrune

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. The Place of In Vitro Maturation in PCO/PCOS.International journal of endocrinology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laurence Foix-L'HéliasEpidemiological Research Unit on Perinatal Health and Women's and Children's Health, Unité Mixte de Recherche S953, INSERM, Paris, France ; Service de Néonatologie, Hôpital Trousseau, Assistance Publique - Hôpitaux de Paris and Université Pierre et Marie Curie, Paris, France.
Michael GrynbergService de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France ; U782, INSERM, Clamart, France.
Béatrice DucotCESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development, INSERM, Villejuif, France ; UMRS 1018, Université Paris-Sud, Villejuif, France.
Nelly FrydmanUnité de Formation et de Recherche Kremlin Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, France ; Service de Biologie de la Reproduction, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.
Violaine KerbratService de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.
Jean BouyerCESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development, INSERM, Villejuif, France ; UMRS 1018, Université Paris-Sud, Villejuif, France.
Philippe LabruneUnité de Formation et de Recherche Kremlin Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, France ; Service de Pédiatrie, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral lines of evidence indicate that immature oocyte retrieval and subsequent in vitro maturation (IVM) without ovarian stimulation may be a reliable option in assisted reproductive technologies (ART). However, few outcome data are available for children born following this technique.

objectiveWe assessed height and weight development of French children conceived after IVM.

methodsAll children conceived after IVM at Antoine Beclere Hospital (Clamart, France) and born between June 2003 and October 2008 (n = 38) were included in a prospective cohort study and compared with a control group of children conceived by ICSI without IVM, matched for maternal age, gestational age and singleton/twin pregnancies. Follow-up included clinical examination at one year and a questionnaire completed by parents when the children were two years old (97% follow-up rate).

resultsNo statistical differences between IVM and control groups were found for boys. Mean weight, height and head circumference at birth were significantly greater for IVM than for ICSI girls (3.236 kg vs 2.701 kg (p = 0.03); 49 cm vs 47 cm (p = 0.01) and 34 cm vs 33 cm (p = 0.04), respectively). At one year, IVM girls remained heavier (mean weight 10.2 kg vs 8.6 kg (p = 0.001)) and taller (76 cm vs 73 cm (p = 0.03)), and there was a two-point difference in BMI between the two groups of girls (18 vs 16 (p = 0.01)).

conclusionOur results in girls born after IVM should be interpreted with caution. It remains unclear whether the observed sexual dimorphism is due to IVM technology or to maternal characteristics such as underlying infertility in patients with polycystic ovary syndrome (PCOS). Further monitoring of the outcomes of these infants is required.

Indexed as

Child DevelopmentFertilization in VitroIn Vitro TechniquesPregnancy OutcomeBirth WeightBody HeightBody WeightCephalometryChild, PreschoolEmbryo TransferFemaleHumansInfantInfant, NewbornMalePolycystic Ovary Syndrome

Identifiers

PMID24586979
PMCPMC3935896

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.