ArticlePloS one2014
Regulation of Drosophila eye development by the transcription factor Sine oculis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Targets of the transcription factor Six1 identify previously unreported candidate deafness genes.Development (Cambridge, England) · 2025Article
- Experimental approaches to investigate biophysical interactions between homeodomain transcription factors and DNA.Biochimica et biophysica acta. Gene regulatory mechanisms · 2025Review
- Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Development of the ocellar visual system in Drosophila melanogaster.The FEBS journal · 2022Article
- Altering enhancer-promoter linear distance impacts promoter competition in cis and in trans.Genetics · 2022Article
- Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease.Genesis (New York, N.Y. : 2000) · 2021Article
- Mutations in SIX1 Associated with Branchio-oto-Renal Syndrome (BOR) Differentially Affect Otic Expression of Putative Target Genes.Journal of developmental biology · 2021Article
- New regulators of Drosophila eye development identified from temporal transcriptome changes.Genetics · 2021Article
- Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development.Disease models & mechanisms · 2020Article
- Multilevel regulation of the glass locus during Drosophila eye development.PLoS genetics · 2019Article
- Glass confers rhabdomeric photoreceptor identity inEvoDevo · 2019Article
- Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.PLoS genetics · 2018Article
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in theDevelopment (Cambridge, England) · 2017Article
- Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.PLoS genetics · 2016Article
- Article
- Conditional knockout of retinal determination genes in differentiating cells in Drosophila.The FEBS journal · 2016Article
- Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.Developmental biology · 2016Article
- Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Glaucoma Genes and Mechanisms.Progress in molecular biology and translational science · 2015Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Homeodomain transcription factors of the Sine oculis (SIX) family direct multiple regulatory processes throughout the metazoans. Sine oculis (So) was first characterized in the fruit fly Drosophila melanogaster, where it is both necessary and sufficient for eye development, regulating cell survival, proliferation, and differentiation. Despite its key role in development, only a few direct targets of So have been described previously. In the current study, we aim to expand our knowledge of So-mediated transcriptional regulation in the developing Drosophila eye using ChIP-seq to map So binding regions throughout the genome. We find 7,566 So enriched regions (peaks), estimated to map to 5,952 genes. Using overlap between the So ChIP-seq peak set and genes that are differentially regulated in response to loss or gain of so, we identify putative direct targets of So. We find So binding enrichment in genes not previously known to be regulated by So, including genes that encode cell junction proteins and signaling pathway components. In addition, we analyze a subset of So-bound novel genes in the eye, and find eight genes that have previously uncharacterized eye phenotypes and may be novel direct targets of So. Our study presents a greatly expanded list of candidate So targets and serves as basis for future studies of So-mediated gene regulation in the eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.