ArticlePloS one2014
Remote control of respiratory neural network by spinal locomotor generators.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanism-Based Neuromodulation in Augmenting Respiratory Motor Function in Individuals with Spinal Cord Injury.Journal of clinical medicine · 2025Review
- Review
- The multifunctionality of the brainstem breathing control circuit.Current opinion in neurobiology · 2025Review
- Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury.Frontiers in neural circuits · 2024Article
- Upregulation of breathing rate during running exercise by central locomotor circuits in mice.Nature communications · 2023Article
- Passive limb training modulates respiratory rhythmic bursts.Scientific reports · 2023Article
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Locomotor-respiratory coupling in ambulatory adults with incomplete spinal cord injury.Spinal cord series and cases · 2022Observational
- Neurogenic mechanisms for locomotor-respiratory coordination in mammals.Frontiers in neuroanatomy · 2022Review
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Breath Tools: A Synthesis of Evidence-Based Breathing Strategies to Enhance Human Running.Frontiers in physiology · 2022Review
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- Impact of Activity-Based Therapy on Respiratory Outcomes in a Medically Complex Child.Children (Basel, Switzerland) · 2021Article
- Article
- Targeted activation of spinal respiratory neural circuits.Experimental neurology · 2020Review
- Diversity of reticulospinal systems in mammals.Current opinion in physiology · 2019Article
- Modulation of Respiratory System by Limb Muscle Afferents in Intact and Injured Spinal Cord.Frontiers in neuroscience · 2019Review
- Role of Propriospinal Neurons in Control of Respiratory Muscles and Recovery of Breathing Following Injury.Frontiers in systems neuroscience · 2019Review
- Activation of Brainstem Neurons During Mesencephalic Locomotor Region-Evoked Locomotion in the Cat.Frontiers in systems neuroscience · 2019Article
- Breathing matters.Nature reviews. Neuroscience · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During exercise and locomotion, breathing rate rapidly increases to meet the suddenly enhanced oxygen demand. The extent to which direct central interactions between the spinal networks controlling locomotion and the brainstem networks controlling breathing are involved in this rhythm modulation remains unknown. Here, we show that in isolated neonatal rat brainstem-spinal cord preparations, the increase in respiratory rate observed during fictive locomotion is associated with an increase in the excitability of pre-inspiratory neurons of the parafacial respiratory group (pFRG/Pre-I). In addition, this locomotion-induced respiratory rhythm modulation is prevented both by bilateral lesion of the pFRG region and by blockade of neurokinin 1 receptors in the brainstem. Thus, our results assign pFRG/Pre-I neurons a new role as elements of a previously undescribed pathway involved in the functional interaction between respiratory and locomotor networks, an interaction that also involves a substance P-dependent modulating mechanism requiring the activation of neurokinin 1 receptors. This neurogenic mechanism may take an active part in the increased respiratory rhythmicity produced at the onset and during episodes of locomotion in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.