Evidence map›Paper›PMID 24586896›Full record

Trial reportPloS one2014

Anthropometrics and body composition by dual energy X-ray in children of obese women: a follow-up of a randomized controlled trial (the Lifestyle in Pregnancy and Offspring [LiPO] study).

Mette Tanvig, Christina A Vinter, Jan S Jørgensen, Sonja Wehberg, Per G Ovesen, Ronald F Lamont, Henning Beck-Nielsen, Henrik T Christesen, Dorte M Jensen

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mette TanvigDepartment of Endocrinology, Odense University Hospital, Odense, Denmark ; Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Christina A VinterDepartment of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Jan S JørgensenDepartment of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Sonja WehbergInstitute of Clinical Research, University of Southern Denmark, Odense, Denmark ; Centre for Clinical Epidemiology, Odense University Hospital, Odense, Denmark.
Per G OvesenDepartment of Gynecology and Obstetrics, Aarhus University Hospital, Skejby, Denmark.
Ronald F LamontDepartment of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark ; Division of Surgery, University College London, London, United Kingdom.
Henning Beck-NielsenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Henrik T ChristesenInstitute of Clinical Research, University of Southern Denmark, Odense, Denmark ; Hans Christian Andersen Childreńs Hospital, Odense University Hospital, Odense, Denmark.
Dorte M JensenDepartment of Endocrinology, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn obese women, 1) to assess whether lower gestational weight gain (GWG) during pregnancy in the lifestyle intervention group of a randomized controlled trial (RCT) resulted in differences in offspring anthropometrics and body composition, and 2) to compare offspring outcomes to a reference group of children born to women with a normal Body Mass Index (BMI). RESEARCH DESIGN AND

methodsThe LiPO (Lifestyle in Pregnancy and Offspring) study was an offspring follow-up of a RCT with 360 obese pregnant women with a lifestyle intervention during pregnancy including dietary advice, coaching and exercise. The trial was completed by 301 women who were eligible for follow-up. In addition, to the children from the RCT, a group of children born to women with a normal BMI were included as a reference group. At 2.8 (range 2.5-3.2) years, anthropometrics were measured in 157 children of the RCT mothers and in 97 reference group children with Body Mass Index (BMI) Z-score as a primary outcome. Body composition was estimated by Dual Energy X-ray (DEXA) in 123 successful scans out of 147 (84%).

resultsNo differences between randomized groups were seen in mean (95% C.I.) BMI Z-score (intervention group 0.06 [-0.17; 0.29] vs. controls -0.18 [-0.43; 0.05]), in the percentage of overweight or obese children (10.9% vs. 6.7%), in other anthropometrics, or in body composition values by DEXA. Outcomes between children from the RCT and the reference group children were not significantly different.

conclusionsThe RCT with lifestyle intervention in obese pregnant women did not result in any detectable effect on offspring anthropometrics or body composition by DEXA at 2.8 years of age. This may reflect the limited difference in GWG between intervention and control groups. Offspring of obese mothers from the RCT were comparable to offspring of mothers with a normal BMI.

Indexed as

Body CompositionBody Mass IndexAbsorptiometry, PhotonAdultCase-Control StudiesChild, PreschoolFemaleFollow-Up StudiesHumansInfantInfant, NewbornLife StyleMaleMothersObesityOverweight

Identifiers

PMID24586896
PMCPMC3933548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.