ArticlePloS one2014
Risk factors for methicillin resistant Staphylococcus aureus: a multi-laboratory study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- European hospitals as source of multidrug-resistant bacteria: analysis of travellers screened in Finland after hospitalization abroad.Journal of travel medicine · 2022Article
- Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal.Tropical medicine and health · 2021Article
- Place in Therapy of the Newly Available Armamentarium for Multi-Drug-Resistant Gram-Negative Pathogens: Proposal of a Prescription Algorithm.Antibiotics (Basel, Switzerland) · 2021Review
- Article
- Methicillin-resistantIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Review
- Effects of the proportion of high-risk patients and control strategies on the prevalence of methicillin-resistant Staphylococcus aureus in an intensive care unit.BMC infectious diseases · 2019Article
- Antibiotic susceptibility patterns ofThe Pan African medical journal · 2019Article
- Predictors of colonization with Staphylococcus species among patients scheduled for cardiac and orthopedic interventions at tertiary care hospitals in north-eastern Germany-a prevalence screening study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP).PloS one · 2018Article
- Characteristics of the antibiotic regimen that affect antimicrobial resistance in urinary pathogens.Antimicrobial resistance and infection control · 2018Article
- Inducible clindamycin and methicillin resistant Staphylococcus aureus in a tertiary care hospital, Kathmandu, Nepal.BMC infectious diseases · 2017Article
- Article
- Environmental monitoring of bacterial contamination and antibiotic resistance patterns of the fecal coliforms isolated from Cauvery River, a major drinking water source in Karnataka, India.Environmental monitoring and assessment · 2015Article
- Colonisation with ESBL-producing and carbapenemase-producing Enterobacteriaceae, vancomycin-resistant enterococci, and meticillin-resistant Staphylococcus aureus in a long-term care facility over one year.BMC infectious diseases · 2015Article
- Article
- Applying Convergent Immunity to Innovative Vaccines Targeting Staphylococcus aureus.Frontiers in immunology · 2014Review
- High prevalence of methicillin resistant staphylococci strains isolated from surgical site infections in Kinshasa.The Pan African medical journal · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study aimed to investigate the dose response relationship between the prescriptions of antimicrobial agents and infection/colonization with methicillin resistant Staphylococcus aureus (MRSA) taking additional factors like stay in a health care facility into account.
methodsMulti-centre retrospective study on a cohort of patients that underwent microbiological diagnostics in Belgium during 2005. The bacteriological results retrieved from 17 voluntary participating clinical laboratories were coupled with the individual antimicrobial consumption patterns (July 2004-December 2005) and other variables as provided by pooled data of health insurance funds. Multivariate analysis was used to identify risk factors for MRSA colonization/infection.
resultsA total of 6844 patients of which 17.5% died in the year 2005, were included in a logistic regression model. More than 97% of MRSA was associated with infection (clinical samples), and only a minority with screening/colonization (1.59%). Factors (95% CI) significantly (p≤<0.01) associated with MRSA in the final multivariate model were: admission to a long term care settings (2.79-4.46); prescription of antibiotics via a hospital pharmacy (1.30-2.01); age 55+ years (3.32-5.63); age 15-54 years (1.23-2.16); and consumption of antimicrobial agent per DDD (defined daily dose) (1.25-1.40).
conclusionsThe data demonstrated a direct dose-response relationship between MRSA and consumption of antimicrobial agents at the individual patient level of 25-40% increased risk per every single day. In addition the study indicated an involvement of specific healthcare settings and age in MRSA status.
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