ArticlePloS one2014
Dynamic monitoring of mechano-sensing of cells by gold nanoslit surface plasmon resonance sensor.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Determination of Half-Maximal Inhibitory Concentration (ICAnalytical chemistry · 2025Article
- Simultaneous assessment of cell morphology and adhesion using aluminum nanoslit-based plasmonic biosensing chips.Scientific reports · 2019Article
- Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics.Scientific reports · 2018Article
- Study of flow rate induced measurement error in flow-through nano-hole plasmonic sensor.Biomicrofluidics · 2015Article
- Label-free detection of rare cell in human blood using gold nano slit surface plasmon resonance.Biosensors · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrated a real-time monitoring of live cells upon laminar shear stress stimulation via surface plasmon resonance (SPR) in gold nanoslit array. A large-area gold nanostructure consisted of 500-nm-period nanoslits was fabricated on a plastic film using the thermal-annealed template-stripping method. The SPR in the gold nanoslit array provides high surface sensitivity to monitor cell adhesion changes near the sensor surface. The human non-small cell lung cancer (CL1-0), human lung fibroblast (MRC-5), and human dermal fibroblast (Hs68) were cultured on the gold nanoslits and their dynamic responses to laminar shear stress were measured under different stress magnitudes from 0 to 30 dyne/cm(2). Cell adhesion was increased in CL1-0 under shear flow stimulation. No adhesion recovery was observed after stopping the flow. On the other hand, MRC-5 and Hs68 decreased adhesion and recovered from the shear stress. The degree of recovery was around 70% for MRC-5. This device provides dynamic study and early detection of cell adhesion changes under shear flow conditions.
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