ArticlePloS one2014
High detection rates of enteropathogens in asymptomatic children attending day care.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 90 citations in OpenAlex.
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- Stool multiplex PCR assay versus conventional stool tests for detecting gastrointestinal infection as a cause for flare of inflammatory bowel disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
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- Improving surveillance of infectious diseases in child daycare settings: insights from a pilot study in the Netherlands.Frontiers in public health · 2026Article
- Rise in the number of notifications of Shiga toxin-producingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Asymptomatic Shedding of Enteric Viruses in Young Children: Insights From a Year-Long Prospective Surveillance Study.Journal of medical virology · 2025Article
- Multiplex Polymerase Chain Reaction Panels for Gastrointestinal Infections: Current Evidence, Regulatory Hurdles, and the Way Forward.Open forum infectious diseases · 2025Article
- Impact of shared spaces and daily routines on shared microbiome.Scientific reports · 2025Article
- Multicenter evaluation of the QIAstat-Dx Gastrointestinal Panel 2, a multiplex PCR platform for the diagnosis of acute gastroenteritis.Journal of clinical microbiology · 2025Article
- Acute infectious gastroenteritis in childhood: the role of rapid multiplex molecular syndromic panels in diagnosis and clinical management.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Review
- Use of gastrointestinal syndromic multiplex molecular assays and detection ofJournal of clinical microbiology · 2025Article
- Diagnosing gastrointestinal infections based on cycle threshold cut-offs of PCR.Microbiology spectrum · 2025Article
- Gastrointestinal Panel Performance for the Diagnosis of Acute Gastroenteritis in Pediatric Patients.Cureus · 2024Article
- Factors Associated With Actionable Gastrointestinal Panel Results in Hospitalized Children.Hospital pediatrics · 2023Article
- Selected commensals educate the intestinal vascular and immune system for immunocompetence.Microbiome · 2022Article
- High prevalence of small intestine bacteria overgrowth and asymptomatic carriage of enteric pathogens in stunted children in Antananarivo, Madagascar.PLoS neglected tropical diseases · 2022Article
- The bacterial community of childcare centers: potential implications for microbial dispersal and child exposure.Environmental microbiome · 2022Article
- From a case-control survey to a diagnostic viral gastroenteritis panel for testing of general practitioners' patients.PloS one · 2021Article
- Prevalence and Effect of Intestinal Infections Detected by a PCR-Based Stool Test in Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastroenteritis morbidity is high among children under the age of four, especially amongst those who attend day care.
objectiveTo determine the prevalence of a range of enteropathogens in the intestinal flora of children attending day care and to relate their occurrence with characteristics of the sampled child and the sampling season.
methodsWe performed three years of enteropathogen surveillance in a network of 29 child day care centers in the Netherlands. The centers were instructed to take one fecal sample from ten randomly chosen children each month, regardless of gastrointestinal symptoms at time of sampling. All samples were analyzed for the molecular detection of 16 enteropathogenic bacteria, parasites and viruses by real-time multiplex PCR.
resultsEnteropathogens were detected in 78.0% of the 5197 fecal samples. Of the total, 95.4% of samples were obtained from children who had no gastroenteritis symptoms at time of sampling. Bacterial enteropathogens were detected most often (most prevalent EPEC, 19.9%), followed by parasitic enteropathogens (most prevalent: D. fragilis, 22.1%) and viral enteropathogens (most prevalent: norovirus, 9.5%). 4.6% of samples related to children that experienced symptoms of gastroenteritis at time of sampling. Only rotavirus and norovirus were significantly associated with gastroenteritis among day care attendees.
conclusionsOur study indicates that asymptomatic infections with enteropathogens in day care attendees are not a rare event and that gastroenteritis caused by infections with these enteropathogens is only one expression of their presence.
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