SynthesisPloS one2014
Low socioeconomic status is associated with worse survival in children with cancer: a systematic review.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Social determinants of health and pediatric cancer survival: A systematic review.Pediatric blood & cancer · 2022Pooled it
- The Effect of Socioeconomic Factors on Outcomes of Distal Radius Fractures: A Systematic Review.Hand (New York, N.Y.) · 2018Pooled it
- Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Comparisons between individual- and area-level measures of socioeconomic status among childhood cancer patients: A report from the Children's Oncology Group (COG).Cancer epidemiology · 2026Article
- Cancer survival and its social determinants among children with a migrant background: systematic review protocol.BMJ open · 2026Article
- The Mediating Effect of Socioeconomic Status and Persistent Poverty on Racial and Ethnic Disparities in Pediatric Cancer Mortality in the United States.Cancer medicine · 2026Article
- The Impact of Distance and Income on Pediatric Solid Extracranial Tumors: A Report From CYP-C.Cancer medicine · 2026Article
- Sociodemographic differences in long-term survival among children and young people with life-limiting conditions: A 10-year cohort analysis using national health insurance data.Palliative care and social practice · 2026Article
- Childhood cancer survival in low- and middle-income countries and the Global South: emerging evidence and critical gaps from a scoping review of observational studies.EJC paediatric oncology · 2025Review
- Socioeconomic background and childhood cancer survival in Germany: A nationwide assessment based on data from the German Childhood Cancer Registry.International journal of cancer · 2025Article
- Area Deprivation and Pediatric Cancer Mortality: An Analysis of 2000 to 2020 State Cancer Registry Data.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.Research square · 2025Article
- Making the case for an International Childhood Cancer Data Partnership.Journal of the National Cancer Institute · 2025Article
- Disparities in cancer incidence, stage at diagnosis, treatment and mortality across socioeconomic groups in Finland: a register-based population study.BMJ public health · 2025Article
- Ewing sarcoma of the thumb presenting in a Hispanic patient: A case report.International journal of surgery case reports · 2024Article
- Inequities in childhood cancer research: A scoping review.EJC paediatric oncology · 2024Article
- Parental Socioeconomic Status and an Infant's Risk of Hospital Admission for Respiratory Syncytial Virus.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Sociodemographic and Socioeconomic Factors Correlate with Late-Stage Pediatric Hodgkin Lymphoma and Rhabdomyosarcoma: A Report from the Children's Oncology Group Registries.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Access to Care for Adolescents and Young Adults With Cancer in the United States: State of the Literature.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- Understanding and addressing race disparities in childhood cancer outcomes.Nature reviews. Cancer · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile low socioeconomic status (SES) has been associated with inferior cancer outcome among adults, its impact in pediatric oncology is unclear. Our objective was therefore to conduct a systematic review to determine the impact of SES upon outcome in children with cancer.
methodsWe searched Ovid Medline, EMBASE and CINAHL from inception to December 2012. Studies for which survival-related outcomes were reported by socioeconomic subgroups were eligible for inclusion. Two reviewers independently assessed articles and extracted data. Given anticipated heterogeneity, no quantitative meta-analyses were planned a priori.
resultsOf 7,737 publications, 527 in ten languages met criteria for full review; 36 studies met final inclusion criteria. In low- and middle-income countries (LMIC), lower SES was uniformly associated with inferior survival, regardless of the measure chosen. The majority of associations were statistically significant. Of 52 associations between socioeconomic variables and outcome among high-income country (HIC) children, 38 (73.1%) found low SES to be associated with worse survival, 15 of which were statistically significant. Of the remaining 14 (no association or high SES associated with worse survival), only one was statistically significant. Both HIC studies examining the effect of insurance found uninsured status to be statistically associated with inferior survival.
conclusionsSocioeconomic gradients in which low SES is associated with inferior childhood cancer survival are ubiquitous in LMIC and common in HIC. Future studies should elucidate mechanisms underlying these gradients, allowing the design of interventions mediating socioeconomic effects. Targeting the effect of low SES will allow for further improvements in childhood cancer survival.
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