Evidence map›Paper›PMID 24586798›Full record

ArticlePloS one2014

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1.

Dawid Dębowski, Michał Pikuła, Marta Lubos, Paulina Langa, Piotr Trzonkowski, Adam Lesner, Anna Łęgowska, Krzysztof Rolka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dawid DębowskiDepartment of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
Michał PikułaDepartment of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland.
Marta LubosDepartment of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
Paulina LangaDepartment of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland.
Piotr TrzonkowskiDepartment of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland.
Adam LesnerDepartment of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
Anna ŁęgowskaDepartment of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
Krzysztof RolkaDepartment of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
University of Gdańsk · PLGdańsk Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starting from the primary structure of sunflower trypsin inhibitor SFTI-1, we designed novel non-covalent inhibitors of human and yeast 20S proteasomes. Peptides with Arg residue in P1 position and two basic amino acid residues (Lys or/and Arg) in P2' and P3' positions strongly inhibited chymotrypsin-like and caspase-like activities, while trypsin-like activity was poorly modified. We found that some SFTI-1 analogues up-regulated exclusively the chymotrypsin-like activity of latent yeast 20S proteasome.

Indexed as

CaspasesChymotrypsinHumansPeptidesPeptides, CyclicProteasome Endopeptidase ComplexTrypsinTrypsin InhibitorsYeastsCaspasesChymotrypsinPeptidesPeptides, CyclicProteasome Endopeptidase ComplexSFTI-1 peptide, sunflowerTrypsinTrypsin Inhibitors

Identifiers

PMID24586798
PMCPMC3934894
OpenAlexW1993181389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.