ArticlePloS one2014
Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints.European journal of nutrition · 2024Trial
- Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation.Physiological reports · 2018Trial
- Low-Cost, Disposable Biosensor for Detection of the Brain-Derived Neurotrophic Factor Biomarker in Noninvasively Collected Saliva toward Diagnosis of Mental Disorders.ACS polymers Au · 2025Article
- Brain-Derived Neurotrophic Factor (BDNF) as a Marker of Physical Exercise or Activity Effectiveness in Fatigue, Pain, Depression, and Sleep Disturbances: A Scoping Review.Biomedicines · 2025Review
- Detection of Major Depressive Disorder Based on a Combination of Voice Features: An Exploratory Approach.International journal of environmental research and public health · 2022Article
- Neuroendocrine, inflammatory, and extracellular vesicle responses during the Navy Special Warfare Screener Selection Course.Physiological genomics · 2022Article
- Performance Evaluation of a Voice-Based Depression Assessment System Considering the Number and Type of Input Utterances.Sensors (Basel, Switzerland) · 2021Article
- Depressive Mood Assessment Method Based on Emotion Level Derived from Voice: Comparison of Voice Features of Individuals with Major Depressive Disorders and Healthy Controls.International journal of environmental research and public health · 2021Article
- Sleep, brain vascular health and ageing.GeroScience · 2020Review
- Evaluation of the Severity of Major Depression Using a Voice Index for Emotional Arousal.Sensors (Basel, Switzerland) · 2020Article
- Effectiveness of a Voice-Based Mental Health Evaluation System for Mobile Devices: Prospective Study.JMIR formative research · 2020Article
- Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Progress in the Development of Intrinsically Conducting Polymer Composites as Biosensors.Macromolecular chemistry and physics · 2019Review
- No gene-by-environment interaction of BDNFEuropean journal of psychotraumatology · 2018Article
- Beneficial effect of fluoxetine treatment aganist psychological stress is mediated by increasing BDNF expression in selected brain areas.Oncotarget · 2017Article
- VEGF-related polymorphisms identified by GWAS and risk for major depression.Translational psychiatry · 2017Article
- Stress, Sleep and Recovery in Elite Soccer: A Critical Review of the Literature.Sports medicine (Auckland, N.Z.) · 2015Review
- Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron.Molecular neurobiology · 2015Article
- Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Observational
- Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression.Neuroscience letters · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decreased concentrations of plasma brain-derived neurotrophic factor (BDNF) and serum BDNF have been proposed to be a state marker of depression and a biological indicator of loaded psychosocial stress. Stress evaluations of participants in military mission are critically important and appropriate objective biological parameters that evaluate stress are needed. In military circumstances, there are several problems to adopt plasma BDNF concentration as a stress biomarker. First, in addition to psychosocial stress, military missions inevitably involve physical exercise that increases plasma BDNF concentrations. Second, most participants in the mission do not have adequate quality or quantity of sleep, and sleep deprivation has also been reported to increase plasma BDNF concentration. We evaluated plasma BDNF concentrations in 52 participants on a 9-week military mission. The present study revealed that plasma BDNF concentration significantly decreased despite elevated serum enzymes that escaped from muscle and decreased quantity and quality of sleep, as detected by a wearable watch-type sensor. In addition, we observed a significant decrease in plasma vascular endothelial growth factor (VEGF) during the mission. VEGF is also neurotrophic and its expression in the brain has been reported to be up-regulated by antidepressive treatments and down-regulated by stress. This is the first report of decreased plasma VEGF concentrations by stress. We conclude that decreased plasma concentrations of neurotrophins can be candidates for mental stress indicators in actual stressful environments that include physical exercise and limited sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.