ArticlePloS one2014
Increased prolactin levels are associated with impaired processing speed in subjects with early psychosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peripheral Biomarkers of Anorexia Nervosa: A Meta-Analysis.Nutrients · 2024Pooled it
- Gender differences in cognitive function in antipsychotic-treated chronic schizophrenia patients with hyperprolactinemia: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Changes in plasma hydrogen sulfide are associated with cognitive improvements in schizophrenia patients treated with atypical antipsychotics.Frontiers in psychiatry · 2026Article
- Effects of hyperprolactinemia and bromocriptine treatment on cerebral blood flow and functional brain States.Neuroradiology · 2025Article
- Mix effect of prolactin on cognitive performance in patients with schizophrenia.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Psychotic symptoms in Chinese adolescent patients with major depressive disorder: prevalence and related endocrine clinical factors.BMC psychiatry · 2024Article
- The Association Between Prolactin Levels and Cognitive Function in Female Patients With Severe Mental Disorders.Psychiatry investigation · 2024Article
- The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Neurobiochemical Disturbances in Psychosis and their Implications for Therapeutic Intervention.Current topics in medicinal chemistry · 2024Review
- Association of Prolactin, Oxytocin, and Homocysteine With the Clinical and Cognitive Features of a First Episode of Psychosis Over a 1-Year Follow-Up.The international journal of neuropsychopharmacology · 2023Article
- The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance.The international journal of neuropsychopharmacology · 2022Article
- Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments.International journal of molecular sciences · 2021Review
- Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas.Frontiers in neurology · 2021Article
- Improvement in Attention Processing After Surgical Treatment in Functional Pituitary Adenomas: Evidence From ERP Study.Frontiers in neurology · 2021Article
- Hormone levels are related to functional compensation in prolactinomas: A resting-state fMRI study.Journal of the neurological sciences · 2020Article
- Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin.Clinical drug investigation · 2020Review
- Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis.Frontiers in psychiatry · 2020Article
- Improvement in cognitive impairment following the successful treatment of endogenous Cushing's syndrome-a case report and literature review.BMC endocrine disorders · 2019Review
- Antidopaminergic medication in healthy subjects provokes subjective and objective mental impairments tightly correlated with perturbation of biogenic monoamine metabolism and prolactin secretion.Neuropsychiatric disease and treatment · 2018Article
- Cognitive Function and Serum Hormone Levels Are Associated with Gray Matter Volume Decline in Female Patients with Prolactinomas.Frontiers in neurology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperprolactinaemia, a common side effect of some antipsychotic drugs, is also present in drug-naïve psychotic patients and subjects at risk for psychosis. Recent studies in non-psychiatric populations suggest that increased prolactin may have negative effects on cognition. The aim of our study was to explore whether high plasma prolactin levels are associated with poorer cognitive functioning in subjects with early psychoses. We studied 107 participants: 29 healthy subjects and 78 subjects with an early psychosis (55 psychotic disorders with <3 years of illness, 23 high-risk subjects). Cognitive assessment was performed with the MATRICS Cognitive Consensus Cognitive Battery, and prolactin levels were determined as well as total cortisol levels in plasma. Psychopathological status was assessed and the use of psychopharmacological treatments (antipsychotics, antidepressants, benzodiazepines) recorded. Prolactin levels were negatively associated with cognitive performance in processing speed, in patients with a psychotic disorder and high-risk subjects. In the latter group, increased prolactin levels were also associated with impaired reasoning and problem solving and poorer general cognition. In a multiple linear regression analysis conducted in both high-risk and psychotic patients, controlling for potential confounders, prolactin and benzodiazepines were independently related to poorer cognitive performance in the speed of processing domain. A mediation analysis showed that both prolactin and benzodiazepine treatment act as mediators of the relationship between risperidone/paliperidone treatment and speed of processing. These results suggest that increased prolactin levels are associated with impaired processing speed in early psychosis. If these results are confirmed in future studies, strategies targeting reduction of prolactin levels may improve cognition in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.