ArticlePloS one2014
Increased risk of stroke after septicaemia: a population-based longitudinal study in Taiwan.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Long-term risk and predictors of cerebrovascular events following sepsis hospitalization: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.Intensive care medicine · 2021Pooled it
- Long-term cardiovascular outcomes and risk factors in adult sepsis survivors: a systematic review and meta-analysis.World journal of emergency medicine · 2025Review
- Bacterial signature in retrieved thrombi of patients with acute ischemic stroke-a systematic review.Therapeutic advances in neurological disorders · 2024Review
- Impact of the initial clinical presentation on the outcome of patients with infective endocarditis.Cardiology journal · 2023Article
- Underestimated Ischemic Heart Disease in Major Adverse Cardiovascular Events after Septicemia Discharge.Medicina (Kaunas, Lithuania) · 2022Article
- New-Onset Atrial Fibrillation Is a Risk Factor of Ischemic Stroke in Chronic Obstructive Pulmonary Disease.Healthcare (Basel, Switzerland) · 2022Article
- Seasonality of Influenza-Like-Illness and Acute Cardiovascular Events Are Related Regardless of Vaccine Effectiveness.Journal of the American Heart Association · 2020Article
- Clots retrieved by mechanical thrombectomy from acute ischemic stroke patients show no evidence of bacteria.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019Article
- Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: a nationwide retrospective cohort study.Postgraduate medical journal · 2019Article
- Article
- Susceptible period for cardiovascular complications in patients recovering from sepsis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Septicemia is associated with increased risk for dementia: a population-based longitudinal study.Oncotarget · 2017Article
- Article
- Article
- Spectrum of Cerebrovascular Disease in Patients with Multiple Myeloma Undergoing Chemotherapy-Results of a Case Control Study.PloS one · 2016Article
- Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology.F1000Research · 2015Review
- The impact of acute kidney injury on the long-term risk of stroke.Journal of the American Heart Association · 2014Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation and infection have been noted to increase stroke risk. However, the association between septicaemia and increased risk of stroke remains unclear. This population-based cohort study, using a National Health Insurance database, aimed to investigate whether patients with septicaemia are predisposed to increased stroke risk. The study included all patients hospitalised for septicaemia for the first time between 2000 and 2003 without prior stroke. Patients were followed until the end of 2010 to evaluate incidence of stroke. An age-, gender- and co-morbidities-matched cohort without prior stroke served as the control. Cox's proportional hazards regressions were used to assess differences in stroke risk between groups. Based on hazard ratios (HRs), patients with septicaemia had greater stroke risk, especially in the younger age groups (age <45: HR = 4.16, 95% CI: 2.39-7.24, p<0.001; age 45-64: HR = 1.76, 95% CI: 1.41-2.19, p<0.001; age ≥ 65: HR = 1.05, 95% CI: 0.91-1.22, p>0.05). Haemorrhagic stroke was the dominant type (ischaemic stroke: HR = 1.20, 95% CI: 1.06-1.37, p<0.01; haemorrhagic stroke: HR = 1.82, 95% CI: 1.35-2.46, p<0.001) and patients without co-morbidities were at slightly higher risk (without co-morbidities: HR = 1.49, 95% CI: 1.02-2.17, p<0.05; with co-morbidities: HR = 1.24, 95% CI: 1.10-1.41, p<0.001). The impact of septicaemia on stroke risk was highest within 6 months of the event and gradually declined over time. Our results suggest that septicaemia is associated with an increase in stroke risk, which is greatest in haemorrhagic stroke. Closer attention to patients with history of septicaemia may be warranted for stroke preventive measures, especially for younger patients without co-morbidities.
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