Evidence map›Paper›PMID 24586723›Full record

ArticlePloS one2014

A prospective study on metabolic risk factors and gallbladder cancer in the metabolic syndrome and cancer (Me-Can) collaborative study.

Wegene Borena, Michael Edlinger, Tone Bjørge, Christel Häggström, Björn Lindkvist, Gabriele Nagel, Anders Engeland, Tanja Stocks, Susanne Strohmaier, Jonas Manjer and 7 more

Erratum issuedOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Metabolic Syndrome and Risk of Gastrointestinal Cancers: An Investigation Using Large-scale Molecular Data.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Article
  15. Article
  16. Review
  17. Comparing Age at Cancer Diagnosis between Hispanics and Non-Hispanic Whites in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

17 authors at 9 institutions in 5 countries.

Wegene BorenaDepartment of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
Michael EdlingerDepartment of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
Tone BjørgeDepartment of Public Health and Primary Health Care, University of Bergen, Bergen, Norway ; Norwegian Institute of Public Health, Oslo/Bergen, Norway.
Christel HäggströmDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Björn LindkvistDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Gabriele NagelInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany ; Agency for Preventive and Social Medicine, Bregenz, Austria.
Anders EngelandDepartment of Public Health and Primary Health Care, University of Bergen, Bergen, Norway ; Norwegian Institute of Public Health, Oslo/Bergen, Norway.
Tanja StocksDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden ; Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Susanne StrohmaierDepartment of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
Jonas ManjerDepartment of Surgery, Malmö University Hospital, Lund University, Malmö, Sweden.
Randi SelmerDepartment of Public Health and Primary Health Care, University of Bergen, Bergen, Norway.
Steinar TretliCancer Registry of Norway, Institute of Population-based Cancer Research, Montebello, Oslo, Norway.
Hans ConcinAgency for Preventive and Social Medicine, Bregenz, Austria.
Goran HallmansDepartment of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden.
Håkan JonssonDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Pär StattinDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Hanno UlmerDepartment of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.
Innsbruck Medical University · ATUmeå University · SEUniversity of Bergen · NOCancer Registry of Norway · NOCopenhagen University Hospital · DKLund University · SENorwegian Institute of Public Health · NOSahlgrenska University Hospital · SEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between metabolic risk factors (individually and in combination) and risk of gallbladder cancer (GBC).

methodsThe metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden with data on 578,700 men and women. We used Cox proportional hazard regression models to calculate relative risks of GBC by body mass index (BMI), blood pressure, and plasma levels of glucose, cholesterol, and triglycerides as continuous standardised variables and their standardised sum of metabolic syndrome (MetS) z-score. The risk estimates were corrected for random error in measurements.

resultsDuring an average follow-up of 12.0 years (SD = 7.8), 184 primary gallbladder cancers were diagnosed. Relative risk of gallbladder cancer per unit increment of z-score adjusted for age, smoking status and BMI (except for BMI itself) and stratified by birth year, sex and sub-cohorts, was for BMI 1.31 (95% confidence interval 1.11, 1.57) and blood glucose 1.76 (1.10, 2.85). Further analysis showed that the effect of BMI on GBC risk is larger among women in the premenopausal age group (1.84 (1.23, 2.78)) compared to those in the postmenopausal age group (1.29 (0.93, 1.79)). For the other metabolic factors no significant association was found (mid blood pressure 0.96 (0.71, 1.31), cholesterol 0.84 (0.66, 1.06) and serum triglycerides 1.16 (0.82, 1.64)). The relative risk per one unit increment of the MetS z-score was 1.37 (1.07, 1.73).

conclusionThis study showed that increasing BMI and impaired glucose metabolism pose a possible risk for gallbladder cancer. Beyond the individual factors, the results also showed that the metabolic syndrome as an entity presents a risk constellation for the occurrence of gallbladder cancer.

Indexed as

AdultAgedAustriaBlood GlucoseCholesterolFemaleFollow-Up StudiesGallbladder NeoplasmsHumansMaleMetabolic SyndromeMiddle AgedNorwayProspective StudiesRisk FactorsSwedenBlood GlucoseCholesterolTriglycerides

Identifiers

PMID24586723
PMCPMC3931760
OpenAlexW2092259072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.