Evidence map›Paper›PMID 24586717›Full record

Trial reportPloS one2014

Difficulties in eliminating measles and controlling rubella and mumps: a cross-sectional study of a first measles and rubella vaccination and a second measles, mumps, and rubella vaccination.

Zhifang Wang, Rui Yan, Hanqing He, Qian Li, Guohua Chen, Shengxu Yang, Enfu Chen

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

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  17. Seroprevalence of Measles Antibodies and Predictors for Seropositivity among Chinese Children.International journal of environmental research and public health · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhifang WangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, P. R. China.
Rui YanZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, P. R. China.
Hanqing HeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, P. R. China.
Qian LiZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, P. R. China.
Guohua ChenCixi City Center for Disease Control and Prevention, Cixi, Ningbo, P. R. China.
Shengxu YangSanmen County Center for Disease Control and Prevention, Sanmen, Taizhou, P. R. China.
Enfu ChenZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, P. R. China.
Zhejiang Center for Disease Control and Prevention · CNChinese Center For Disease Control and Prevention · CNNingbo Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe reported coverage of the measles-rubella (MR) or measles-mumps-rubella (MMR) vaccine is greater than 99.0% in Zhejiang province. However, the incidence of measles, mumps, and rubella remains high. In this study, we assessed MMR seropositivity and disease distribution by age on the basis of the current vaccination program, wherein the first dose of MR is administered at 8 months and the second dose of MMR is administered at 18-24 months.

methodsCross-sectional serological surveys of MMR antibodies were conducted by collecting epidemiological data in Zhejiang province, China in 2011. In total, 1015 participants were randomly selected from two surveillance sites. Serum MMR-specific immunoglobulin G levels were tested by enzyme-linked immunosorbent assay. The geometric mean titers and seroprevalence with 95% confidence intervals (CIs) were calculated by age and gender. Proportions of different dose of vaccine by age by vaccine were also identified. Statistically significant differences between categories were assessed by the Chi-square test.

resultsOver 95% seroprevalence rates of measles were seen in all age groups except <7 months infants. Children aged 5-9 years were shown lower seropositivity rates of mumps while elder adolescences and young adults were presented lower rubella seroprevalence. Especially, rubella seropositivity was significantly lower in female adults than in male. Nine measles cases were unvaccinated or unknown vaccination history. Among them, 66.67% (6/9) patients were aged 20-29 years while 33.33% (3/9) were infants aged 8-12 months. In addition, 57.75% (648/1122) patients with mumps were children aged 5-9 years, and 50.54% (94/186) rubella cases were aged 15-39 years.

conclusionsA timely two-dose MMR vaccination schedule is recommended, with the first dose at 8 months and the second dose at 18-24 months. An MR vaccination speed-up campaign may be necessary for elder adolescents and young adults, particularly young females.

Indexed as

AdolescentAdultAntibodies, ViralChildChild, PreschoolChinaCross-Sectional StudiesFemaleHumansIncidenceInfantInfant, NewbornMaleMeaslesMeasles-Mumps-Rubella VaccineMiddle AgedAntibodies, ViralMeasles-Mumps-Rubella VaccineMumps VaccineRubella Vaccine

Identifiers

PMID24586717
PMCPMC3930734
OpenAlexW2047409767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.