ArticlePloS one2014
Arachidonic acid enhances turnover of the dermal skeleton: studies on zebrafish scales.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Melanin concentrating hormone regulates bone cell activities and calcium metabolism in regenerating goldfish scales.Scientific reports · 2026Article
- Melatonin suppresses the plasma calcium level in female goldfish during the late and post-reproductive stages.Scientific reports · 2025Article
- Synthesis and Biological Evaluations of Granulatamide B and its Structural Analogues.Current medicinal chemistry · 2024Article
- Evaluation of Post-Larval Diets for Indoor Weaned Largemouth Bass (Animals : an open access journal from MDPI · 2023Article
- Review
- Evaluation of Dexamethasone-Induced Osteoporosis In Vivo Using Zebrafish Scales.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Unique and non-redundant function ofDevelopment (Cambridge, England) · 2020Article
- Article
- Melatonin is a potential drug for the prevention of bone loss during space flight.Journal of pineal research · 2019Article
- Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.PloS one · 2019Article
- Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds.Frontiers in endocrinology · 2019Review
- Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together.BioMed research international · 2019Review
- Sanggenon C Stimulates Osteoblastic Proliferation and Differentiation, Inhibits Osteoclastic Resorption, and Ameliorates Prednisone-Induced Osteoporosis in Zebrafish Model.Molecules (Basel, Switzerland) · 2018Article
- Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny.PloS one · 2018Article
- High dietary arachidonic acid levels induce changes in complex lipids and immune-related eicosanoids and increase levels of oxidised metabolites in zebrafish (Danio rerio).The British journal of nutrition · 2017Article
- Fish scale is a suitable model for analyzing determinants of skeletal fragility in type 2 diabetes.Endocrine · 2016Article
- Alendronate rescued osteoporotic phenotype in a model of glucocorticoid-induced osteoporosis in adult zebrafish scale.International journal of experimental pathology · 2015Article
- Repairing quite swimmingly: advances in regenerative medicine using zebrafish.Disease models & mechanisms · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fish nutrition, the ratio between omega-3 and omega-6 poly-unsaturated fatty acids influences skeletal development. Supplementation of fish oils with vegetable oils increases the content of omega-6 fatty acids, such as arachidonic acid in the diet. Arachidonic acid is metabolized by cyclooxygenases to prostaglandin E2, an eicosanoid with effects on bone formation and remodeling. To elucidate effects of poly-unsaturated fatty acids on developing and existing skeletal tissues, zebrafish (Danio rerio) were fed (micro-) diets low and high in arachidonic acid content. Elasmoid scales, dermal skeletal plates, are ideal to study skeletal metabolism in zebrafish and were exploited in the present study. The fatty acid profile resulting from a high arachidonic acid diet induced mild but significant increase in matrix resorption in ontogenetic scales of adult zebrafish. Arachidonic acid affected scale regeneration (following removal of ontogenetic scales): mineral deposition was altered and both gene expression and enzymatic matrix metalloproteinase activity changed towards enhanced osteoclastic activity. Arachidonic acid also clearly stimulates matrix metalloproteinase activity in vitro, which implies that resorptive effects of arachidonic acid are mediated by matrix metalloproteinases. The gene expression profile further suggests that arachidonic acid increases maturation rate of the regenerating scale; in other words, enhances turnover. The zebrafish scale is an excellent model to study how and which fatty acids affect skeletal formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.